Figure 4.

Intake of intravenously injected PKH26-labeled exosomes in the brain. (a) A flow chart of the experimental procedure showed the process of labeling exosomes with PKH26 and then injection in vivo. Exosomes purified from the serum were labeled with PKH26, exhibiting the red fluorescence, and administered intravenously to the recipient rat. (b) Representative images of the brain sections of the recipient rat. PKH26-labeled exosomes were shown in red, and DAPI-labeled nucleuses were shown in blue. White arrowheads indicated PKH26-labeled exosomes (magnification, ×400).