Figure 7.

The more effective dosage of MCC950, the specific inhibitor of NLRP3, for inhibiting hippocampal (H) and cortical (C) neuronal pyroptosis induced by HIRI. (a) Representative images of western blotting demonstrating the pyroptosis-related protein of the hippocampus and cortex for each experimental group. (b–g) Quantitative photometric analyses of western blotting illustrate the pyroptosis-related protein of the hippocampus and cortex for each experimental group. n = 5 per group. Data are presented as the mean ± SD. ^∗p < 0.05 vs. the sham group; ^∗∗p < 0.01 vs. the sham group; ^∗∗∗p < 0.0001 vs. the sham group; ^#p < 0.05 vs. the IR group; ^##p < 0.01 vs. the IR group; ^###p < 0.0001 vs. the IR group.