Table II.

Treatment regimens and mortality data of the trials included in the meta-analysis.

First author (year)	Treatment timing	Drug	Dosing and course of treatment	Intention (prevention or treatment)	Mortality end-point	Mortality status (dead/alive)	(Refs.)
Weigelt (1985)	Early	MTPS	120 mg/kg/d for 2 d	Treatment	Hospital	GC: 11/14	(4)
						Control: 6/8
Bernard (1987)	Early	MTPS	120 mg/kg/d for 1 d	Treatment	45 d	GC: 30/20	(11)
						Control: 31/18
Luce (1988)	Early	MTPS	8 mg/kg/d for 1 d	Prevention	Hospital	GC: 9/4	(5)
						Control: 12/2
Meduri (1998)	Later	MTPS	2 mg/kg/d for 4 d	Treatment	Hospital	GC: 2/14	(12)
			and tapering; 32 d			Control: 5/3
Confalonieri (2005)	Early	Hyd	Single 200 mg	Treatment	Hospital	GC: 0/23	(13)
			followed by		and 60 d	Control: 7/16
			240 mg/d; 7 d
Steinberg (2006)	Later	MTPS	Single 2 mg/kg	Treatment	60 d	GC: 28/61	(6)
			followed by			Control: 29/62
			2 mg/kg/d for 14 d
			and tapering; 25 d
Annane (2006)	Early	Hyd	200 mg/d; 7 d	Treatment	28 d	GC: 54/31	(14)
						Control: 67/25
Meduri (2007)	Early	MTPS	Single 1 mg/kg	Treatment	Hospital	GC: 15/48	(7)
			followed by			Control: 12/16
			1 mg/kg/d for 14 d
			and tapering; 28 d
Seam (2012)	Early	MTPS	1 mg/kg/d for 14 d	Treatment	ICU stay	GC: 11/44	(15)
			and tapering; 28 d			Control: 10/14
Tongyoo (2016)	Early	Hyd	50 mg 4/d; 7 d	Treatment	60 d	GC: 34/64	(16)
						Control: 40/59

MTPS, methylprednisolone; Hyd, hydrocortisone; GC, glucocorticoid; ICU, intensive care unit; d, days.