Table III.
Methodological quality assessment for each of the studies included.
| First author (year) | Randomization | Allocation concealment | Blinding | Inclusion and exclusion criteria defined | Similar baseline at study entry | Treatment protocol clearly described | Cointervention that may affect outcome | Outcome definition | Extent of follow-upclearly described | Intention-to-treat analysis | Final score | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Weigelt (1985) | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 6 | (4) |
| Bernard (1987) | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 7 | (11) |
| Luce (1988) | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 6 | (5) |
| Meduri (1998) | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 9 | (12) |
| Confalonieri (2005) | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 7 | (13) |
| Steinberg (2006) | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 8 | (6) |
| Annane (2006) | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 6 | (14) |
| Meduri (2007) | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 6 | (7) |
| Seam (2012) | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 7 | (15) |
| Tongyoo (2016) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 10 | (16) |