Table IV.
Correlation between TILs in invasive primary tumor front, tumor cell deposits, and distant metastasis to liver and parameters of disease progression in patients with colorectal cancer.
| TILs associated with the invasive front of primary tumor (N=123) | TILs associated with the deposits of cancer cells (N=25) | TILs associated with the invasive front of distant metastasis to liver (N=15) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variables | Low (%) | High (%) | P-value | Low (%) | High (%) | P-value | Low (%) | High (%) | P-value |
| pT stage | |||||||||
| 1 | 2 (1.6) | 1 (0.8) | NS | 0 (0) | 0 (0) | NS | 0 (0) | 0 (0) | 0.004 |
| 2 | 31 (25.2) | 23 (18.6) | 6 (24) | 3 (12.0) | 1 (6.6) | 0 (0) | |||
| 3 | 38 (31.1) | 27 (21.9) | 12 (45,4) | 3 (12.0) | 9 (60) | 3 (20.0) | |||
| 4 | 1 (0.8) | 0 (0) | 1 (6.6) | 0 (0) | 1 (6.6) | 1 (6.6) | |||
| Venous invasion | |||||||||
| Absent | 51 (41.6) | 39 (31.7) | 0.012 | 10 (40) | 4 (16) | NS | 4 (60) | 2 (13.3) | NS |
| Present | 21 (17) | 12 (9.7) | 8 (32) | 3 (12.0) | 7 (40) | 2 (13.3) | |||
| Lymphatic invasion | |||||||||
| Absent | 58 (60.3) | 39 (31.7) | 0.009 | 13 (38) | 2 (8) | NS | 6 (66.6) | 4 (26.6) | NS |
| Present | 26 (21.2) | 12 (9.7) | 5 (22) | 5 (22) | 5 (33.6) | 0 (0) | |||
| Perineural invasion | |||||||||
| Absent | 65 (52.9) | 48 (39.1) | 0.017 | 15 (57.4) | 6 (24) | NS | 10 (93.3) | 4 (26.6) | NS |
| Present | 7 (5.6) | 3 (2.4) | 3 (12.0) | 1 (6.6) | 1 (6.6) | 0 (0) | |||
| Number of removed lymph nodes | |||||||||
| <5 | 8 (6.5) | 2 (1.6) | NS | 2 (8) | 1 (6.6) | NS | 1 (6.6) | 0 (0) | NS |
| 5–10 | 13 (10.5) | 12 (9.7) | 2 (8) | 1 (6.6) | 2 (13.3) | 0 (0) | |||
| >10 | 51 (41.6) | 37 (30.1) | 14 (48.8) | 5 (22) | 8 (53.4) | 4 (26.6) | |||
| Lymph node metastasis | |||||||||
| Absent | 42 (38.2) | 34 (27.6) | 0.022 | 7 (28) | 3 (12.0) | NS | 6 (40) | 2 (13.3) | 0.006 |
| Present | 30 (21.2) | 16 (13) | 11 (44) | 4 (16) | 5 (33.4) | 2 (13.3) | |||
| Number of metastatic lymph nodes | |||||||||
| <5 | 28 (85.4) | 8 (6.5) | 0.007 | 8 (53.3) | 2 (13.3) | NS | 3 (20.0) | 1 (6.6) | NS |
| >5 | 8 (6.5) | 2 (1.6) | 4 (20.1) | 2 (13.3) | 2 (13.3) | 1 (6.6) | |||
| Lymph node pouch invasion | |||||||||
| Absent | 10 (8.3) | 2(1.6) | NS | 2 (13.3) | 1 (6.6) | NS | 7 (66.7) | 3 (20.0) | NS |
| Present | 30 (21.2) | 4 (4.8) | 6 (40) | 6 (40) | 4 (26.6) | 1 (6.6) | |||
| Distant metastasis | |||||||||
| Absent | – | – | – | 15 (62) | 5 (22) | NS | 0 (0) | 0 (0) | NS |
| Present | 2 (8) | 2 (8) | 11 (100) | 4 (26.6) | |||||
| Distant metastasis size (mm) | |||||||||
| <10 | – | – | – | 2 (8) | 0 (0) | NS | 9 (60) | 3 (20.0) | NS |
| >10 | 2 (8) | 0 (0) | 3 (26.7) | 1 (6.6) | |||||
| Tumor deposits | |||||||||
| Absent | – | – | – | 0 (0) | 0 (0) | NS | 9 (60) | 2 (13.3) | 0.052 |
| Present | 18 (72) | 7 (28) | 2 (13.3) | 2 (13.3) | |||||
| Inflammatory cell infiltrate in the invasive front of tumor | |||||||||
| Absent | 8 (6.5) | 7 (5.6) | 0.002 | 2 (8) | 1 (6.6) | 0.042 | 2 (13.3) | 1 (6.6) | NS |
| Weak | 31 (25.2) | 23 (18.6) | 6 (24) | 4 (16) | 3 (20.0) | 2 (13.3) | |||
| Moderate | 17 (14.2) | 15 (12.1) | 7 (28) | 2 (8) | 5 (33.6) | 1 (6.6) | |||
| Strong | 16 (13) | 6 (4.8) | 3 (12.0) | 0 (0) | 1 (6.6) | 0 (0) | |||
| Inflammatory cell infiltrate in the center of tumor mass | |||||||||
| Absent | 6 (4.8) | 3 (2.4) | 0.003 | 1 (6.6) | 0 (0) | NS | 1 (6.6) | 0 (0) | NS |
| Weak | 21 (19.5) | 33 (24.5) | 11 (34.2) | 5 (22) | 9 (60) | 3 (20.0) | |||
| Moderate | 32 (26) | 12 (9.7) | 3 (12.0) | 1 (6.6) | 0 (0) | 1 (6.6) | |||
| Strong | 10 (8.3) | 6 (4.8) | 3 (12.0) | 1 (6.6) | 1 (6.6) | 0 (0) | |||
NS, not statistically significant; TILs, tumor infiltrating lymphocytes.