Table I.
Mouse experimental grouping and means of drug administration.
| Group | Drug doses administered | Drug administration modes | Duration of drug administration |
|---|---|---|---|
| Vehicle control | 0 MES/PZ | N/A | N/A |
| 0 DES | N/A | N/A | |
| UC only | 0 MES/PZ | N/A | N/A |
| 3.6 g/kg/day DSS | PO | Three times/day for 7 days | |
| UC + MES | 300 mg/kg MES | IR | Once a day for 10 days |
| 3.6 g/kg/day DSS | PO | Three times/day for 7 days | |
| UC + PZ L | 60 mg/kg PZ | IR | Once a day for 10 days |
| 3.6 g/kg/day DSS | PO | Three times/day for 7 days | |
| UC + PZ H | 120 mg/kg PZ | IR | Once a day for 10 days |
| 3.6 g/kg/day DSS | PO | Three times/day for 7 days |
N=8 mice/experimental group. DSS, dextran sodium sulfate; H, high-dose; IR, intrarectal; L, low-dose; MES, mesalamine; PZ, polaprezinc; UC, ulcerative colitis. PO, per os, intragastric administration.