Table II.

Significantly altered pathways in the gene set enrichment analysis.

A, Lactate group
Term	ES	NES	P-value	FDR
Cell cycle	−0.47	−1.53	<0.01	0.06
Oxidative phosphorylation	−0.41	−1.35	0.04	0.13
B, Hypoxia group
Term	ES	NES	P-value	FDR
Hedgehog signaling pathway	0.60	1.66	0.01	0.04
Oxidative phosphorylation	−0.40	−1.39	0.02	0.14
C, Hypoxia-lactate group
Term	ES	NES	P-value	FDR
mTOR signaling pathway	0.54	1.77	0.01	0.01
Glycolysis gluconeogenesis	0.49	1.59	0.01	0.04
Hedgehog signaling pathway	0.48	1.54	0.01	0.04
Oxidative phosphorylation	−0.41	−1.35	0.05	0.12
Cell cycle	−0.44	−1.41	0.02	0.15
MAPK signaling pathway	0.28	1.18	0.05	0.19

ES, enrichment score; NES, normalized ES; FDR, false discovery rate; MAPK, mitogen-activated protein kinase.