Fig. 6.

Performance of E&R and GWAS. (A) Performance of GWAS with different population sizes and E&R studies using a powerful (green; 90 → 10%) and a suboptimal selection regime (red; constant 20%). The E&R study with an optimized selection regime has a higher power to identify QTNs than the evaluated GWAS. (B) Manhattan plot for a GWAS (N = 8,000). The effect sizes of QTNs are shown in a color gradient, where large effect loci are red. (C) Manhattan plot for an E&R study (N = 1,000, powerful selection regime). (D) Histogram of the effect sizes recovered with GWAS and E&R. The 2,000 most significant SNPs were used for each approach. The GWAS recovered mostly loci of large effect size whereas the E&R also recovered many loci of small effect. A summary over ten experiments is shown.