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. 2019 Nov 19;9:1258. doi: 10.3389/fonc.2019.01258

Figure 7.

Figure 7

Clinicopathological relevance of TIGAR expression. (A) The IHC analysis of TIGAR protein expression from human gastric cancer tissue microarrays. (B) Comparison of TIGAR expression between tumor and adjacent tissues. The expression of TIGAR in gastric cancer tissues was significantly higher than that in adjacent non-cancerous tissues (n = 42, p < 0.01). (C) Correlation of TIGAR expression in relation to clinicopathologic variables of 84 gastric cancer patients. There was significant difference between TIGAR high expression and low expression patients in respect of mean age (p = 0.04), N staging (p = 0.002), AJCC staging (p = 0.015). (D) Overall survival of gastric cancer patients with high or low TIGAR expression was analyzed by Kaplan-Meier analysis. The 5-year survival rate of patients with high TIGAR expression was significantly lower than those with low TIGAR expression (p = 0.033). (E) The 5-year overall survival on different clinicopathological factors.