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. Author manuscript; available in PMC: 2019 Nov 26.
Published in final edited form as: Cancer Res. 2018 Aug 28;78(21):6235–6246. doi: 10.1158/0008-5472.CAN-18-0634

Figure 6.

Figure 6.

Effects of MEKi and STAT3i on cancer stem cells (CSCs) in PKT mice. Single cell suspension isolated from pancreatic tumors of PKT mice treated with AZD1480, AZD6244 or AZD1480/AZD6244 were analyzed for CSC population by flow cytometry. A, CD44+ tumor cell populations (CD45NegEpCam+CD44+) were significantly decreased in the combined MEKi/STAT3i treatment compared to STAT3i alone or the vehicle groups. B, CD133+ tumor cell populations (CD45NegEpCam+CD133+) were significantly decreased in the combination MEKi/STAT3i compared to the vehicle treated group. *, P < 0.05; **, P < 0.01; ns, P > 0.05.