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. Author manuscript; available in PMC: 2021 Jan 16.
Published in final edited form as: J Proteomics. 2019 Nov 1;211:103544. doi: 10.1016/j.jprot.2019.103544

Figure 5. Molecular dynamics analysis of the rapamycin-induced FKBP-25 F145A/I223P double mutant disorder-to-order transition.

Figure 5.

Wild type, ligand-free, and ligand-bound mutant proteins are shown in green, cyan, and magenta, respectively. The I223P mutation is indicated in blue. The overall protein structure is preserved between all three proteins. The β-sheet secondary structure in the region of the mutation is lost in the non-ligand-bound mutant protein and is recovered in the ligand-bound form of the mutant protein.