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. Author manuscript; available in PMC: 2019 Nov 26.
Published in final edited form as: Cell Rep. 2019 Sep 24;28(13):3497–3509.e4. doi: 10.1016/j.celrep.2019.08.051

Figure 4. 85% of the Replication Fork Proteome Validates with Loss-of-Function Phenotypes or Known Roles in DNA Replication and Repair.

Figure 4.

(A) Pie chart depicting phenotypes observed from the drug sensitivity analyses and existing literature. Loss-of-function (LOF) phenotype includes sensitivity, resistance, and toxicity. Literature indicates published evidence for a function in DNA replication, repair, or related process.

(B) Venn diagram comparing proteins that when depleted result in sensitivity to ATRi, CPT, and HU. Low- and high-dose HU lists are combined for this analysis.

(C) List of the 28 proteins with loss of function resulting in sensitivity to ATRi, CPT, and HU.

See also Figure S3.