Table 2. Correlation matrix comparing lung microbiome composition with lung function and arterial stiffness parameters among young and elderly subjects.
| FEV1 | FVC | FEV1 (%pred) |
FVC (%pred) |
AIx | PWV | ||
|---|---|---|---|---|---|---|---|
| Young | SDI | −0.362 (0.082) |
−0.411 (0.031)* |
−0.546 (0.006)** |
−0.573 (0.003)** |
−0.068 (0.769) |
0.132 (0.569) |
| ISI | −0.396 (0.055) |
−0.460 (0.024)* |
−0.440 (0.032)* |
−0.482 (0.017)* |
0.009 (0.967) |
0.169 (0.465) |
|
| Firmicutes | 0.318 (0.130) |
0.390 (0.060) |
0.363 (0.081) |
0.409 (0.047)* |
0.159 (0.492) |
0.160 (0.489) |
|
| Gemella | 0.082 (0.704) |
0.017 (0937) |
−0.348 (0.095) |
−0.422 (0.040)* |
−0.072 (0.756) |
−0.080 (0.732) |
|
| Actinobacteria | −0.055 (0.799) |
−0.070 (0.747) |
0.064 (0.767) |
0.023 (0.916) |
0.019 (0.935) |
−0.121 (0.603) |
|
| Actinomyces |
−0.408 (0.048)* |
−0.391 (0.059) |
−0.198 (0.354) |
−0.142 (0.508) |
−0.119 (0.608) |
0.205 (0.372) |
|
| Fusobacteria | −0.151 (0.480) |
−0.168 (0.432) |
−0.395 (0.056) |
−0.364 (0.080) |
0.014 (0.953) |
0.146 (0.528) |
|
| Leptotrichia | −0.132 (0.538) |
−0.112 (0.603) |
−0.353 (0.090) |
−0.216 (0.310) |
0.012 (0.960) |
0.170 (0.461) |
|
| Lautropia | 0.043 (0.843) |
−0.124 (0.563) |
0.015 (0.944) |
−0.209 (0.327) |
−0.492 (0.023)* |
−0.420 (0.058) |
|
| Elderly | SDI | −0.151 (0.493) |
−0.157 (0.475) |
−0.155 (0.481) |
−0.086 (0.696) |
0.035 (0.870) |
−0.516 (0.010)* |
| ISI | −0.216 (0.323) |
−0.206 (0.346) |
−0.112 (0.611) |
−0.017 (0.939) |
0.055 (0.789) |
−0.568 (0.004)** |
|
| Firmicutes | 0.190 (0.386) |
0.099 (0.653) |
−0.031 (0.888) |
−0.200 (0.360) |
0.193 (0.366) |
0.118 (0.582) |
|
| Gemella | −0.259 (0.232) |
−0.215 (0.324) |
−0.032 (0.887) |
0.082 (0.710) |
0.124 (0.564) |
0.280 (0.186) |
|
| Actinobacteria | 0.347 (0.105) |
0.447 (0.033)* |
0.382 (0.072) |
0.322 (0.134) |
0.137 (0.522) |
0.097 (0.651) |
|
| Actinomyces | 0.230 (0.290) |
0.238 (0.274) |
0.124 (0.572) |
0.073 (0.742) |
0.023 (0.915) |
−0.350 (0.094) |
|
| Fusobacteria | −0.361 (0.091) |
−0.344 (0.108) |
−0.286 (0.187) |
−0.114 (0.605) |
0.083 (0.701) |
−0.570 (0.004)** |
|
| Leptotrichia | −0.284 (0.189) |
−0.221 (0.310) |
−0.318 (0.139) |
−0.157 (0.473) |
0.207 (0.332) |
−0.569 (0.004)** |
|
| Lautropia | −0.088 (0.690) |
−0.112 (0.612) |
0.254 (0.242) |
0.080 (0.716) |
0.034 (0.873) |
−0.093 (0.665) |
Microbiome indices of alpha diversity including the Shannon diversity index (SDI) and inverse Simpson index (ISI) as well as specific phyla and genera showing significant correlation with lung function (FEV1, FVC, FEV1%predicted, FVC %predicted) and arterial stiffness (augmentation index (AIx) and pulse wave velocity (PWV)) are displayed for younger and elderly sub-groups. p values are shown in brackets. Significantly correlation scores are indicated by bold typeface.
*p < 0.05,
**p < 0.01.