Table 1. Characteristics of paediatric intensive care unit patients by oxygenation response to intravenous methylprednisolone.
| Characteristic | Responders(n = 46) | Non-responders(n = 32) | p-value |
|---|---|---|---|
| Age in months, median(IQR) | 9.0 (5.0–22.0) | 13.0 (6.8–36.0) | 0.22 |
| Unit–GOSH n (%) | 15 (33) | 9 (28) | 0.80 |
| Unit ICH n (%) | 31 (67) | 23 (72) | |
| Diagnosis pneumonia n (%) | 32 (70) | 24 (75) | 0.51 |
| Diagnosis sepsis n (%) | 5 (11) | 1 (3) | |
| Diagnosis post surgery n(%) | 3 (7) | 4 (9) | |
| Diagnosis other n (%) | 6 (13) | 3 (7) | |
| Immune compromise n (%) | 8 (17) | 4 (9) | 0.75 |
| Premature n (%) | 19 (41) | 17 (53) | 0.36 |
| Direct injury n (%) | 38 (83) | 27 (84) | 1.00 |
| Infection n (%) | 36 (78) | 24 (75) | 0.79 |
| Prior steroid exposure n (%) | 9 (20) | 8 (25) | 0.78 |
| Inhaled nitric oxide use prior toinitiation of steroid n (%) | 22 (48) | 22 (69) | 0.1 |
| PIM-3, median (IQR) | 0.067 (0.27–0.12) | 0.05 (0.27–0.08) | 0.37 |
| Oxygenation Saturation Index on day of start of steroids median(IQR) | 13.1 (9.4–18.4) | 14.0 (10.2–20.5) | 0.65 |
| Days ventilated prior to start of steroids median(IQR) | 9.5 (6.0–12.0) | 9.0 (6.0–14.0) | 0.51 |
| PELOD on day of starting steroid median(IQR) | 10.0 (1.0–11.0) | 10.5 (1.0–11.3) | 0.74 |
| Neuro-muscular blockade prior to steroids (%) | 44 (96) | 30 (94) | 1 |
| Proning prior to steroids (%) | 23 (50) | 19 (59) | 0.49 |
| Fluid balance on day of starting steroids, ml/kg Median (IQR) |
90.6 (25.8–183.7) | 84.7 (20.1–163.1) | 0.87 |
| Survival at ICU discharge n (%) | 34 (74) | 13 (41) | 0.005 |