Table 3.

Associations between validated cortical regions and CBCL syndrome scale attention problems in Generation-R.

Cortical region	B	SE	CI lower	CI upper	β	p-value	FDR p- value
Surface area
caudal middle frontal gyrus	−14.10	5.49	−24.87	−3.33	−0.04	0.01	0.03
lateral orbitofrontal cortex	−8.28	5.01	−18.10	1.54	−0.02	0.10	0.11
middle temporal gyrus	−13.63	5.86	−25.12	−2.14	−0.03	0.02	0.04
posterior cingulate cortex	−5.02	2.42	−9.77	−0.27	−0.03	0.04	0.06
rostral anterior cingulate cortex	−3.50	1.93	−7.29	0.29	−0.03	0.07	0.09
superior frontal gyrus	−7.16	11.93	−30.55	16.24	−0.01	0.55	0.55
total surface area	−323.79	77.50	−475.75	−171.82	−0.04	<0.001	<0.001
total surface area (residualized*)	−291.62	77.43	−443.44	−139.79	−0.07	<0.001	<0.001
Thickness
fusiform gyrus	0.004	0.002	0.000	0.01	0.04	0.05	0.054
temporal pole	0.01	0.01	−0.001	0.03	0.04	0.07	0.07

Note: Regions are the average of left and right hemisphere surface area, and are the regions showing significant group differences in split-half analyses (ST15 and ST16). Model is adjusted for age, sex, and ethnic background. ICV is also included as a covariate in the surface area analysis. B is the unstandardized regression coefficient for the square root transformed CBCL syndrome scale attention problems score, and CI is the 95% confidence interval of that regression coefficient. β is the standardized regression coefficient.

^*Given the high correlation between total surface area and ICV, we also tested a model where total surface area was first regressed on ICV, and the resulting residuals were used in the model described above, but without entering ICV. This shows that multicolinearity is not driving the effects. p-values in bold are considered significant, surviving correction for multiple comparisons with FDR q-value<0.05.