Table 1:
Screening test characteristics used in the analysis.
| Test Characteristic | Value (Range) | Varied in Sensitivity Analysis | Source |
|---|---|---|---|
| Test Characteristic | |||
| Sensitivity of FOBT | 0.643 (0.356, 0.86) | No | 14, 15 |
| Sensitivity of FIT | 0.818 (0.478, 0.968) | No | 14, 15 |
| Sensitivity of Colonoscopy | 0.95 (0.92, 0.99) | No | 15–17 |
| Sensitivity of Diagnostic Colonoscopy | 0.95 (0.92, 0.99) | No | 15, 16 |
| Sensitivity of Flex Sig | 0.75 (0.72, 0.85) | No | 15, 18 |
| Sensitivity of DNA | 0.923 (0.83, 0.975) | No | 15, 19, 20 |
| Sensitivity of CT Colonography | 0.922 (0.84, .93) | No | 15, 21, 22 |
| Sensitivity of Test X (Set to match DNA) | 0.923 (0.83, 0.975) | No | |
| Sensitivity of DNA Testing for Adenoma | 0.424 (0.389–0.46) | No | 15, 19, 20 |
| Sensitivity of CT Colonography for Adenoma | 0.8 (0.045–1) | No | 15, 22 |
| Sensitivity of Test X for Adenoma (relative to colonoscopy) | 0.5 (0.5–1) | No | |
| Specificity of FOBT | 0.901 (0.893, 0.908) | No | 14, 15 |
| Specificity of FIT | 0.969 (0.964, 0.974) | No | 14, 15 |
| Specificity of Colonoscopy | 0.9 (0.9, 1) | No | 15, 16 |
| Specificity of Diagnostic Colonoscopy | 0.9 (0.9, 1) | No | 15, 16 |
| Specificity of Flex Sig | 0.92 (0.92, 1) | No | 15, 16, 18, 23 |
| Specificity of DNA | 0.866 (0.859, 0.872) | No | 15, 19, 20 |
| Specificity of CT Colonography | 0.82 (0.796, 0.88) | No | 15, 21, 22 |
| Specificity of Test X (Set to match DNA) | 0.866 (0.859, 0.872) | No | |
| Test Compliance | |||
| Compliance Referent | 1 | ||
| Compliance with FOBT | 0.462 (0.462, 1) | Yes | 24 |
| Compliance with FIT- extrapolated using FOBT | 0.462 (0.462, 1) | Yes | 24 |
| Compliance with FOBT + Flex Sig- extrapolated using Flex Sig | 0.63 (0.63, 1) | Yes | 25 |
| Compliance with FIT + Flex Sig- extrapolated using Flex Sig | 0.63 (0.63, 1) | Yes | 25 |
| Compliance with Colonoscopy- extrapolated using Flex Sig | 0.63 (0.63, 1) | Yes | 25, 26 |
| Compliance with Flex Sig | 0.63 (0.63, 1) | Yes | 25 |
| Compliance with FOBT 2 | 0.597 (0.597, 1) | Yes | 24, 27 |
| Compliance with FIT 2 | 0.597 (0.597, 1) | Yes | 24, 27 |
| Compliance with FOBT 2 + Flex Sig | 0.63 (0.63, 1) | Yes | 25 |
| Compliance with FIT 2 + Flex Sig | 0.63 (0.63, 1) | Yes | 25 |
| Compliance with DNA 1- extrapolated using FOBT | 0.462 (0.462, 1) | Yes | 24 |
| Compliance with DNA 3- extrapolated using FOBT 2 | 0.597 (0.597, 1) | Yes | 24, 27 |
| Compliance with Test X - extrapolated using FOBT | 0.462 (0.462, 1) | Yes | 24 |
| Compliance with Test X 3 - extrapolated using FOBT 2 | 0.597 (0.597, 1) | Yes | 24, 27 |
| Compliance with Test X 5- extrapolated using Flex Sig | 0.63 (0.63, 1) | Yes | 25 |
| Compliance with CT Colonography- extrapolated using Flex Sig | 0.63 (0.63, 1) | Yes | 25 |