Table 4.
Exploratory two-way analysis for the adenoma detection sensitivity and cost for Test X. Comparisons made only for colonoscopy strategy as the domiannt strategy in the primary analyses and 3 strategies built on Test X.
| Comparative Effectiveness | Cost Effectiveness | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Test × Costs = $25 | Test × Costs = $75 | Test × Costs = $150 | Test × Costs = $200 | Test × Costs = $300 | Test × Costs = $400 | Test × Costs = $500 | ||||||||||||||||||||||||||||||||||
| Assumptions | Sensitivity for Adenoma Detection | Strategy | LY | CRC Diagnosed | CRC Prevented | Costs | ICER | Status (Rank) | Costs | ICER | Status (Rank) | Costs | ICER | Status (Rank) | Costs | ICER | Status (Rank) | Costs | ICER | Status (Rank) | Costs | ICER | Status (Rank) | Costs | ICER | Status (Rank) | ||||||||||||||
|
Base Case Cost Model A |
50% | ST 5: Colonoscopy | 15.235 | 3,521 | 1,032 | $ | 3,001 | $ | 46,231 | UD (2) | $ | 3,001 | $ | 11,296 | UD (2) | $ | 3,001 | $ | 0 | UD (1) | $ | 3,001 | $ | 0 | UD (1) | $ | 3,001 | $ | 0 | UD (1) | $ | 3,001 | $ | 0 | UD (1) | $ | 3,001 | $ | 0 | UD (1) |
| ST 14: Test X | 15.231 | 3,787 | 760 | $ | 3,037 | $ | (−) | AD | $ | 3,154 | $ | (−) | AD | $ | 3,329 | $ | (−) | AD | $ | 3,445 | $ | (−) | AD | $ | 3,679 | $ | (−) | AD | $ | 3,912 | $ | (−) | AD | $ | 4,150 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.232 | 3,643 | 903 | $ | 2,880 | $ | 0 | UD (1) | $ | 2,973 | $ | 12,668 | ED | $ | 3,113 | $ | (−) | AD | $ | 3,207 | $ | (−) | AD | $ | 3,393 | $ | (−) | AD | $ | 3,579 | $ | (−) | AD | $ | 3,770 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.231 | 3,757 | 790 | $ | 2,888 | $ | (−) | AD | $ | 2,957 | $ | 0 | UD (1) | $ | 3,062 | $ | (−) | AD | $ | 3,132 | $ | (−) | AD | $ | 3,272 | $ | (−) | AD | $ | 3,411 | $ | (−) | AD | $ | 3,554 | $ | (−) | AD | ||
| 60% | ST 5: Colonoscopy | 15.218 | 3,492 | 1,068 | $ | 3,149 | $ | 100,657 | UD (2) | $ | 3,149 | $ | 71,782 | UD (2) | $ | 3,149 | $ | 28,469 | UD (2) | $ | 3,149 | $ | 0 | UD (1) | $ | 3,149 | $ | 0 | UD (1) | $ | 3,149 | $ | 0 | UD (1) | $ | 3,149 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.211 | 3,747 | 807 | $ | 3,174 | $ | (−) | AD | $ | 3,291 | $ | (−) | AD | $ | 3,465 | $ | (−) | AD | $ | 3,582 | $ | (−) | AD | $ | 3,815 | $ | (−) | AD | $ | 4,049 | $ | (−) | AD | $ | 4,287 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.215 | 3,555 | 1,003 | $ | 2,917 | $ | (−) | AD | $ | 3,011 | $ | (−) | AD | $ | 3,150 | $ | (−) | AD | $ | 3,244 | $ | (−) | AD | $ | 3,430 | $ | (−) | AD | $ | 3,617 | $ | (−) | AD | $ | 3,807 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.215 | 3,647 | 910 | $ | 2,905 | $ | 0 | UD (1) | $ | 2,975 | $ | 0 | UD (1) | $ | 3,080 | $ | 0 | UD (1) | $ | 3,150 | $ | (−) | AD | $ | 3,290 | $ | (−) | AD | $ | 3,430 | $ | (−) | AD | $ | 3,572 | $ | (−) | AD | ||
| 70% | ST 5: Colonoscopy | 15.218 | 3,470 | 1,024 | $ | 2,910 | $ | 105,984 | UD (2) | $ | 2,910 | $ | 73,999 | UD (2) | $ | 2,910 | $ | 26,021 | UD (2) | $ | 2,910 | $ | 0 | UD (1) | $ | 2,910 | $ | 0 | UD (1) | $ | 2,910 | $ | 0 | UD (1) | $ | 2,910 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.211 | 3,680 | 801 | $ | 2,970 | $ | (−) | AD | $ | 3,086 | $ | (−) | AD | $ | 3,260 | $ | (−) | AD | $ | 3,376 | $ | (−) | AD | $ | 3,608 | $ | (−) | AD | $ | 3,840 | $ | (−) | AD | $ | 4,072 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.216 | 3,461 | 1,024 | $ | 2,703 | $ | (−) | AD | $ | 2,796 | $ | (−) | AD | $ | 2,936 | $ | (−) | AD | $ | 3,029 | $ | (−) | AD | $ | 3,215 | $ | (−) | AD | $ | 3,401 | $ | (−) | AD | $ | 3,587 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.216 | 3,547 | 942 | $ | 2,679 | $ | 0 | UD (1) | $ | 2,749 | $ | 0 | UD (1) | $ | 2,853 | $ | 0 | UD (1) | $ | 2,923 | $ | (−) | AD | $ | 3,063 | $ | (−) | AD | $ | 3,202 | $ | (−) | AD | $ | 3,342 | $ | (−) | AD | ||
| 80% | ST 5: Colonoscopy | 15.199 | 3,576 | 1,027 | $ | 3,073 | $ | 477,084 | UD (3) | $ | 3,073 | $ | 353,451 | UD (2) | $ | 3,073 | $ | 202,133 | UD (2) | $ | 3,073 | $ | 101,254 | UD (2) | $ | 3,073 | $ | 0 | UD (1) | $ | 3,073 | $ | 0 | UD (1) | $ | 3,073 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.192 | 3,803 | 788 | $ | 3,162 | $ | (−) | AD | $ | 3,279 | $ | (−) | AD | $ | 3,454 | $ | (−) | AD | $ | 3,571 | $ | (−) | AD | $ | 3,804 | $ | (−) | AD | $ | 4,037 | $ | (−) | AD | $ | 4,270 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.199 | 3,506 | 1,093 | $ | 2,786 | $ | 302,875 | UD (2) | $ | 2,880 | $ | 564,770 | ED | $ | 3,020 | $ | 957,615 | ED | $ | 3,114 | $ | (−) | AD | $ | 3,300 | $ | (−) | AD | $ | 3,487 | $ | (−) | AD | $ | 3,674 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.198 | 3,578 | 1,023 | $ | 2,759 | $ | 0 | UD (1) | $ | 2,829 | $ | 0 | UD (1) | $ | 2,934 | $ | 0 | UD (1) | $ | 3,003 | $ | 0 | UD (1) | $ | 3,143 | $ | (−) | AD | $ | 3,282 | $ | (−) | AD | $ | 3,422 | $ | (−) | AD | ||
| 90% | ST 5: Colonoscopy | 15.225 | 3,591 | 1,007 | $ | 3,057 | $ | (−) | AD | $ | 3,057 | $ | (−) | AD | $ | 3,057 | $ | (−) | AD | $ | 3,057 | $ | (−) | AD | $ | 3,057 | $ | (−) | AD | $ | 3,057 | $ | 0 | UD (1) | $ | 3,057 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.222 | 3,742 | 852 | $ | 2,940 | $ | (−) | AD | $ | 3,056 | $ | (−) | AD | $ | 3,230 | $ | (−) | AD | $ | 3,346 | $ | (−) | AD | $ | 3,578 | $ | (−) | AD | $ | 3,810 | $ | (−) | AD | $ | 4,042 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.225 | 3,427 | 1,169 | $ | 2,659 | $ | (−) | AD | $ | 2,752 | $ | (−) | AD | $ | 2,892 | $ | (−) | AD | $ | 2,986 | $ | (−) | AD | $ | 3,172 | $ | (−) | AD | $ | 3,359 | $ | (−) | AD | $ | 3,545 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.225 | 3,490 | 1,110 | $ | 2,628 | $ | 0 | UD (1) | $ | 2,698 | $ | 0 | UD (1) | $ | 2,802 | $ | 0 | UD (1) | $ | 2,872 | $ | 0 | UD (1) | $ | 3,012 | $ | 0 | UD (1) | $ | 3,152 | $ | 303,965 | UD (2) | $ | 3,291 | $ | 751,893 | UD (2) | ||
| 100% | ST 5: Colonoscopy | 15.198 | 3,536 | 1,030 | $ | 3,032 | $ | (−) | AD | $ | 3,032 | $ | (−) | AD | $ | 3,032 | $ | (−) | AD | $ | 3,032 | $ | (−) | AD | $ | 3,032 | $ | (−) | AD | $ | 3,032 | $ | (−) | AD | $ | 3,032 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.193 | 3,681 | 890 | $ | 3,004 | $ | (−) | AD | $ | 3,120 | $ | (−) | AD | $ | 3,295 | $ | (−) | AD | $ | 3,412 | $ | (−) | AD | $ | 3,645 | $ | (−) | AD | $ | 3,878 | $ | (−) | AD | $ | 4,112 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.201 | 3,278 | 1,293 | $ | 2,571 | $ | (−) | AD | $ | 2,665 | $ | (−) | AD | $ | 2,804 | $ | (−) | AD | $ | 2,897 | $ | (−) | AD | $ | 3,084 | $ | (−) | AD | $ | 3,270 | $ | (−) | AD | $ | 3,456 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.201 | 3,333 | 1,238 | $ | 2,503 | $ | 0 | UD (1) | $ | 2,572 | $ | 0 | UD (1) | $ | 2,677 | $ | 0 | UD (1) | $ | 2,747 | $ | 0 | UD (1) | $ | 2,886 | $ | 0 | UD (1) | $ | 3,026 | $ | 0 | UD (1) | $ | 3,165 | $ | 36,504 | UD (2) | ||
|
Alternate
Case Cost Model A |
50% | ST 5: Colonoscopy | 15.199 | 3,503 | 989 | $ | 3,021 | $ | 94,226 | UD (2) | $ | 3,021 | $ | 48,963 | UD (2) | $ | 3,021 | $ | 0 | UD (1) | $ | 3,021 | $ | 0 | UD (1) | $ | 3,021 | $ | 0 | UD (1) | $ | 3,021 | $ | 0 | UD (1) | $ | 3,021 | $ | 0 | UD (1) |
| ST 14: Test X | 15.191 | 3,835 | 644 | $ | 3,103 | $ | (−) | AD | $ | 3,249 | $ | (−) | AD | $ | 3,468 | $ | (−) | AD | $ | 3,614 | $ | (−) | AD | $ | 3,905 | $ | (−) | AD | $ | 4,197 | $ | (−) | AD | $ | 4,494 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.196 | 3,674 | 805 | $ | 2,805 | $ | 0 | UD (1) | $ | 2,909 | $ | 0 | UD (1) | $ | 3,064 | $ | (−) | AD | $ | 3,168 | $ | (−) | AD | $ | 3,376 | $ | (−) | AD | $ | 3,584 | $ | (−) | AD | $ | 3,796 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.194 | 3,773 | 706 | $ | 2,861 | $ | (−) | AD | $ | 2,936 | $ | (−) | AD | $ | 3,048 | $ | (−) | AD | $ | 3,123 | $ | (−) | AD | $ | 3,273 | $ | (−) | AD | $ | 3,423 | $ | (−) | AD | $ | 3,576 | $ | (−) | AD | ||
| 60% | ST 5: Colonoscopy | 15.209 | 3,529 | 1,041 | $ | 3,016 | $ | 41,882 | UD (2) | $ | 3,016 | $ | 18,181 | UD (2) | $ | 3,016 | $ | 0 | UD (1) | $ | 3,016 | $ | 0 | UD (1) | $ | 3,016 | $ | 0 | UD (1) | $ | 3,016 | $ | 0 | UD (1) | $ | 3,016 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.200 | 3,837 | 729 | $ | 3,158 | $ | (−) | AD | $ | 3,303 | $ | (−) | AD | $ | 3,521 | $ | (−) | AD | $ | 3,666 | $ | (−) | AD | $ | 3,957 | $ | (−) | AD | $ | 4,248 | $ | (−) | AD | $ | 4,544 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.205 | 3,649 | 923 | $ | 2,862 | $ | 0 | UD (1) | $ | 2,966 | $ | 47,627 | ED | $ | 3,122 | $ | (−) | AD | $ | 3,226 | $ | (−) | AD | $ | 3,434 | $ | (−) | AD | $ | 3,642 | $ | (−) | AD | $ | 3,854 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.204 | 3,744 | 826 | $ | 2,864 | $ | (−) | AD | $ | 2,939 | $ | 0 | UD (1) | $ | 3,051 | $ | (−) | AD | $ | 3,126 | $ | (−) | AD | $ | 3,276 | $ | (−) | AD | $ | 3,426 | $ | (−) | AD | $ | 3,579 | $ | (−) | AD | ||
| 70% | ST 5: Colonoscopy | 15.211 | 3,543 | 1,020 | $ | 2,978 | $ | 62,598 | UD (3) | $ | 2,978 | $ | 43,216 | UD (2) | $ | 2,978 | $ | 14,768 | UD (2) | $ | 2,978 | $ | 0 | UD (1) | $ | 2,978 | $ | 0 | UD (1) | $ | 2,978 | $ | 0 | UD (1) | $ | 2,978 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.205 | 3,758 | 800 | $ | 2,954 | $ | (−) | AD | $ | 3,099 | $ | (−) | AD | $ | 3,318 | $ | (−) | AD | $ | 3,463 | $ | (−) | AD | $ | 3,754 | $ | (−) | AD | $ | 4,046 | $ | (−) | AD | $ | 4,343 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.207 | 3,558 | 1,003 | $ | 2,742 | $ | 54,077 | UD (2) | $ | 2,846 | $ | 203,631 | ED | $ | 3,002 | $ | (−) | AD | $ | 3,107 | $ | (−) | AD | $ | 3,315 | $ | (−) | AD | $ | 3,523 | $ | (−) | AD | $ | 3,736 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.207 | 3,641 | 922 | $ | 2,732 | $ | 0 | UD (1) | $ | 2,807 | $ | 0 | UD (1) | $ | 2,920 | $ | 0 | UD (1) | $ | 2,995 | $ | (−) | AD | $ | 3,145 | $ | (−) | AD | $ | 3,295 | $ | (−) | AD | $ | 3,449 | $ | (−) | AD | ||
| 80% | ST 5: Colonoscopy | 15.200 | 3,491 | 1,046 | $ | 2,972 | $ | 132,699 | UD (2) | $ | 2,972 | $ | 96,378 | UD (2) | $ | 2,972 | $ | 52,126 | UD (2) | $ | 2,972 | $ | 22,624 | UD (2) | $ | 2,972 | $ | 0 | UD (1) | $ | 2,972 | $ | 0 | UD (1) | $ | 2,972 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.193 | 3,678 | 858 | $ | 2,976 | $ | (−) | AD | $ | 3,121 | $ | (−) | AD | $ | 3,340 | $ | (−) | AD | $ | 3,485 | $ | (−) | AD | $ | 3,777 | $ | (−) | AD | $ | 4,068 | $ | (−) | AD | $ | 4,365 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.197 | 3,402 | 1,136 | $ | 2,641 | $ | 0 | UD (1) | $ | 2,745 | $ | 354,029 | ED | $ | 2,901 | $ | 1,185,813 | ED | $ | 3,005 | $ | (−) | AD | $ | 3,213 | $ | (−) | AD | $ | 3,421 | $ | (−) | AD | $ | 3,634 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.197 | 3,486 | 1,057 | $ | 2,651 | $ | (−) | AD | $ | 2,726 | $ | 0 | UD (1) | $ | 2,839 | $ | 0 | UD (1) | $ | 2,914 | $ | 0 | UD (1) | $ | 3,065 | $ | (−) | AD | $ | 3,215 | $ | (−) | AD | $ | 3,368 | $ | (−) | AD | ||
| 90% | ST 5: Colonoscopy | 15.202 | 3,490 | 1,053 | $ | 3,025 | $ | (−) | AD | $ | 3,025 | $ | (−) | AD | $ | 3,025 | $ | (−) | AD | $ | 3,025 | $ | (−) | AD | $ | 3,025 | $ | (−) | AD | $ | 3,025 | $ | 0 | UD (1) | $ | 3,025 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.195 | 3,626 | 916 | $ | 2,982 | $ | (−) | AD | $ | 3,129 | $ | (−) | AD | $ | 3,349 | $ | (−) | AD | $ | 3,495 | $ | (−) | AD | $ | 3,788 | $ | (−) | AD | $ | 4,081 | $ | (−) | AD | $ | 4,380 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.203 | 3,302 | 1,242 | $ | 2,557 | $ | 9,385 | UD (2) | $ | 2,661 | $ | 36,935 | UD (2) | $ | 2,817 | $ | 78,261 | UD (2) | $ | 2,922 | $ | 105,812 | UD (2) | $ | 3,130 | $ | 160,914 | UD (2) | $ | 3,339 | $ | 294,357 | UD (2) | $ | 3,551 | $ | 493,876 | UD (2) | ||
| ST 16: Test X 5 | 15.202 | 3,381 | 1,163 | $ | 2,547 | $ | 0 | UD (1) | $ | 2,622 | $ | 0 | UD (1) | $ | 2,735 | $ | 0 | UD (1) | $ | 2,810 | $ | 0 | UD (1) | $ | 2,961 | $ | 0 | UD (1) | $ | 3,111 | $ | 7,487,781 | ED | $ | 3,264 | $ 20,846,524 | ED | |||
| 100% | ST 5: Colonoscopy | 15.207 | 3,477 | 1,060 | $ | 3,053 | $ | (−) | AD | $ | 3,053 | $ | (−) | AD | $ | 3,053 | $ | (−) | AD | $ | 3,053 | $ | (−) | AD | $ | 3,053 | $ | (−) | AD | $ | 3,053 | $ | (−) | AD | $ | 3,053 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.206 | 3,527 | 1,005 | $ | 2,877 | $ | (−) | AD | $ | 3,023 | $ | (−) | AD | $ | 3,242 | $ | (−) | AD | $ | 3,387 | $ | (−) | AD | $ | 3,679 | $ | (−) | AD | $ | 3,971 | $ | (−) | AD | $ | 4,268 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.210 | 3,149 | 1,393 | $ | 2,498 | $ | (−) | AD | $ | 2,602 | $ | (−) | AD | $ | 2,758 | $ | (−) | AD | $ | 2,862 | $ | (−) | AD | $ | 3,070 | $ | (−) | AD | $ | 3,278 | $ | (−) | AD | $ | 3,490 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.212 | 3,235 | 1,309 | $ | 2,422 | $ | 0 | UD (1) | $ | 2,497 | $ | 0 | UD (1) | $ | 2,609 | $ | 0 | UD (1) | $ | 2,684 | $ | 0 | UD (1) | $ | 2,834 | $ | 0 | UD (1) | $ | 2,983 | $ | 0 | UD (1) | $ | 3,136 | $ | 17,602 | UD (2) | ||
|
Base Case Cost Model B |
50% | ST 5: Colonoscopy | 15.186 | 3,492 | 1,028 | $ | 3,923 | $ | 80,809 | UD (3) | $ | 3,923 | $ | 62,370 | UD (2) | $ | 3,923 | $ | 38,977 | UD (2) | $ | 3,923 | $ | 23,382 | UD (2) | $ | 3,923 | $ | 0 | UD (1) | $ | 3,923 | $ | 0 | UD (1) | $ | 3,923 | $ | 0 | UD (1) |
| ST 14: Test X | 15.178 | 3,784 | 726 | $ | 3,986 | $ | (−) | AD | $ | 4,103 | $ | (−) | AD | $ | 4,277 | $ | (−) | AD | $ | 4,394 | $ | (−) | AD | $ | 4,627 | $ | (−) | AD | $ | 4,860 | $ | (−) | AD | $ | 5,098 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.183 | 3,620 | 888 | $ | 3,640 | $ | 67,867 | UD (2) | $ | 3,734 | $ | 91,940 | ED | $ | 3,874 | $ | 128,050 | ED | $ | 3,968 | $ | (−) | AD | $ | 4,155 | $ | (−) | AD | $ | 4,342 | $ | (−) | AD | $ | 4,533 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.182 | 3,736 | 771 | $ | 3,573 | $ | 0 | UD (1) | $ | 3,643 | $ | 0 | UD (1) | $ | 3,748 | $ | 0 | UD (1) | $ | 3,818 | $ | 0 | UD (1) | $ | 3,958 | $ | (−) | AD | $ | 4,097 | $ | (−) | AD | $ | 4,240 | $ | (−) | AD | ||
| 60% | ST 5: Colonoscopy | 15.216 | 3,498 | 1,023 | $ | 3,883 | $ | 86,563 | UD (2) | $ | 3,883 | $ | 69,381 | UD (2) | $ | 3,883 | $ | 43,609 | UD (2) | $ | 3,883 | $ | 26,427 | UD (2) | $ | 3,883 | $ | 0 | UD (1) | $ | 3,883 | $ | 0 | UD (1) | $ | 3,883 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.210 | 3,717 | 799 | $ | 3,827 | $ | (−) | AD | $ | 3,944 | $ | (−) | AD | $ | 4,120 | $ | (−) | AD | $ | 4,237 | $ | (−) | AD | $ | 4,471 | $ | (−) | AD | $ | 4,705 | $ | (−) | AD | $ | 4,944 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.211 | 3,552 | 967 | $ | 3,552 | $ | (−) | AD | $ | 3,645 | $ | (−) | AD | $ | 3,785 | $ | (−) | AD | $ | 3,878 | $ | (−) | AD | $ | 4,064 | $ | (−) | AD | $ | 4,251 | $ | (−) | AD | $ | 4,441 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.212 | 3,654 | 868 | $ | 3,531 | $ | 0 | UD (1) | $ | 3,601 | $ | 0 | UD (1) | $ | 3,706 | $ | 0 | UD (1) | $ | 3,776 | $ | 0 | UD (1) | $ | 3,916 | $ | (−) | AD | $ | 4,056 | $ | (−) | AD | $ | 4,198 | $ | (−) | AD | ||
| 70% | ST 5: Colonoscopy | 15.200 | 3,598 | 994 | $ | 3,950 | $ | 235,646 | UD (3) | $ | 3,950 | $ | 181,858 | UD (3) | $ | 3,950 | $ | 120,075 | UD (2) | $ | 3,950 | $ | 91,763 | UD (2) | $ | 3,950 | $ | 35,138 | UD (2) | $ | 3,950 | $ | 0 | UD (1) | $ | 3,950 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.194 | 3,801 | 782 | $ | 3,845 | $ | (−) | AD | $ | 3,961 | $ | (−) | AD | $ | 4,136 | $ | (−) | AD | $ | 4,253 | $ | (−) | AD | $ | 4,487 | $ | (−) | AD | $ | 4,720 | $ | (−) | AD | $ | 4,958 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.198 | 3,595 | 994 | $ | 3,542 | $ | 85,569 | UD (2) | $ | 3,635 | $ | 117,141 | UD (2) | $ | 3,774 | $ | 164,499 | ED | $ | 3,868 | $ | 196,071 | ED | $ | 4,054 | $ | (−) | AD | $ | 4,240 | $ | (−) | AD | $ | 4,430 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.197 | 3,673 | 917 | $ | 3,479 | $ | 0 | UD (1) | $ | 3,549 | $ | 0 | UD (1) | $ | 3,653 | $ | 0 | UD (1) | $ | 3,723 | $ | 0 | UD (1) | $ | 3,863 | $ | 0 | UD (1) | $ | 4,003 | $ | (−) | AD | $ | 4,145 | $ | (−) | AD | ||
| 80% | ST 5: Colonoscopy | 15.208 | 3,514 | 1,052 | $ | 4,005 | $ | 1,946,310 | UD (2) | $ | 4,005 | $ | 1,717,452 | UD (2) | $ | 4,005 | $ | 1,374,166 | UD (2) | $ | 4,005 | $ | 1,145,309 | UD (2) | $ | 4,005 | $ | 687,595 | UD (2) | $ | 4,005 | $ | 229,881 | UD (2) | $ | 4,005 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.200 | 3,736 | 817 | $ | 3,996 | $ | (−) | AD | $ | 4,112 | $ | (−) | AD | $ | 4,286 | $ | (−) | AD | $ | 4,402 | $ | (−) | AD | $ | 4,633 | $ | (−) | AD | $ | 4,865 | $ | (−) | AD | $ | 5,102 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.206 | 3,430 | 1,135 | $ | 3,532 | $ | (−) | AD | $ | 3,625 | $ | (−) | AD | $ | 3,764 | $ | (−) | AD | $ | 3,857 | $ | (−) | AD | $ | 4,043 | $ | (−) | AD | $ | 4,230 | $ | (−) | AD | $ | 4,419 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.207 | 3,472 | 1,093 | $ | 3,412 | $ | 0 | UD (1) | $ | 3,482 | $ | 0 | UD (1) | $ | 3,586 | $ | 0 | UD (1) | $ | 3,656 | $ | 0 | UD (1) | $ | 3,795 | $ | 0 | UD (1) | $ | 3,935 | $ | 0 | UD (1) | $ | 4,077 | $ | (−) | AD | ||
| 90% | ST 5: Colonoscopy | 15.197 | 3,540 | 1,031 | $ | 4,039 | $ | (−) | AD | $ | 4,039 | $ | (−) | AD | $ | 4,039 | $ | (−) | AD | $ | 4,039 | $ | (−) | AD | $ | 4,039 | $ | (−) | AD | $ | 4,039 | $ | (−) | AD | $ | 4,039 | $ | (−) | AD | |
| ST 14: Test X | 15.195 | 3,701 | 866 | $ | 3,818 | $ | (−) | AD | $ | 3,935 | $ | (−) | AD | $ | 4,110 | $ | (−) | AD | $ | 4,227 | $ | (−) | AD | $ | 4,461 | $ | (−) | AD | $ | 4,694 | $ | (−) | AD | $ | 4,933 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.198 | 3,360 | 1,212 | $ | 3,407 | $ | (−) | AD | $ | 3,500 | $ | (−) | AD | $ | 3,641 | $ | (−) | AD | $ | 3,734 | $ | (−) | AD | $ | 3,921 | $ | (−) | AD | $ | 4,108 | $ | (−) | AD | $ | 4,299 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.200 | 3,418 | 1,153 | $ | 3,310 | $ | 0 | UD (1) | $ | 3,380 | $ | 0 | UD (1) | $ | 3,485 | $ | 0 | UD (1) | $ | 3,555 | $ | 0 | UD (1) | $ | 3,695 | $ | 0 | UD (1) | $ | 3,835 | $ | 0 | UD (1) | $ | 3,978 | $ | 0 | UD (1) | ||
| 100% | ST 5: Colonoscopy | 15.206 | 3,542 | 1,038 | $ | 4,138 | $ | (−) | AD | $ | 4,138 | $ | (−) | AD | $ | 4,138 | $ | (−) | AD | $ | 4,138 | $ | (−) | AD | $ | 4,138 | $ | (−) | AD | $ | 4,138 | $ | (−) | AD | $ | 4,138 | $ | (−) | AD | |
| ST 14: Test X | 15.201 | 3,643 | 932 | $ | 3,973 | $ | (−) | AD | $ | 4,090 | $ | (−) | AD | $ | 4,266 | $ | (−) | AD | $ | 4,383 | $ | (−) | AD | $ | 4,618 | $ | (−) | AD | $ | 4,853 | $ | (−) | AD | $ | 5,092 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.207 | 3,278 | 1,308 | $ | 3,392 | $ | (−) | AD | $ | 3,486 | $ | (−) | AD | $ | 3,626 | $ | (−) | AD | $ | 3,720 | $ | (−) | AD | $ | 3,908 | $ | (−) | AD | $ | 4,095 | $ | (−) | AD | $ | 4,287 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.209 | 3,346 | 1,239 | $ | 3,337 | $ | 0 | UD (1) | $ | 3,407 | $ | 0 | UD (1) | $ | 3,512 | $ | 0 | UD (1) | $ | 3,582 | $ | 0 | UD (1) | $ | 3,722 | $ | 0 | UD (1) | $ | 3,862 | $ | 0 | UD (1) | $ | 4,005 | $ | 0 | UD (1) | ||
|
Alternate
Case Cost Model B |
50% | ST 5: Colonoscopy | 15.228 | 3,527 | 1,068 | $ | 3,910 | $ | 48,143 | UD (2) | $ | 3,910 | $ | 34,571 | UD (2) | $ | 3,910 | $ | 14,212 | UD (2) | $ | 3,910 | $ | 639 | UD (2) | $ | 3,910 | $ | 0 | UD (1) | $ | 3,910 | $ | 0 | UD (1) | $ | 3,910 | $ | 0 | UD (1) |
| ST 14: Test X | 15.217 | 3,832 | 748 | $ | 4,037 | $ | (−) | AD | $ | 4,184 | $ | (−) | AD | $ | 4,404 | $ | (−) | AD | $ | 4,551 | $ | (−) | AD | $ | 4,844 | $ | (−) | AD | $ | 5,138 | $ | (−) | AD | $ | 5,437 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.222 | 3,733 | 856 | $ | 3,695 | $ | (−) | AD | $ | 3,799 | $ | (−) | AD | $ | 3,956 | $ | (−) | AD | $ | 4,061 | $ | (−) | AD | $ | 4,270 | $ | (−) | AD | $ | 4,479 | $ | (−) | AD | $ | 4,692 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.222 | 3,840 | 748 | $ | 3,643 | $ | 0 | UD (1) | $ | 3,719 | $ | 0 | UD (1) | $ | 3,832 | $ | 0 | UD (1) | $ | 3,907 | $ | 0 | UD (1) | $ | 4,057 | $ | (−) | AD | $ | 4,208 | $ | (−) | AD | $ | 4,362 | $ | (−) | AD | ||
| 60% | ST 5: Colonoscopy | 15.219 | 3,477 | 1,050 | $ | 3,853 | $ | 68,354 | UD (2) | $ | 3,853 | $ | 49,092 | UD (3) | $ | 3,853 | $ | 16,246 | UD (2) | $ | 3,853 | $ | 16,246 | UD (2) | $ | 3,853 | $ | 0 | UD (1) | $ | 3,853 | $ | 0 | UD (1) | $ | 3,853 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.211 | 3,755 | 762 | $ | 3,788 | $ | (−) | AD | $ | 3,935 | $ | (−) | AD | $ | 4,300 | $ | (−) | AD | $ | 4,300 | $ | (−) | AD | $ | 4,592 | $ | (−) | AD | $ | 4,885 | $ | (−) | AD | $ | 5,183 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.214 | 3,608 | 914 | $ | 3,484 | $ | 0 | UD (1) | $ | 3,588 | $ | 33,220 | UD (2) | $ | 3,848 | $ | 155,167 | ED | $ | 3,848 | $ | 155,167 | ED | $ | 4,056 | $ | (−) | AD | $ | 4,264 | $ | (−) | AD | $ | 4,477 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.213 | 3,689 | 835 | $ | 3,494 | $ | (−) | AD | $ | 3,569 | $ | 0 | UD (1) | $ | 3,756 | $ | 0 | UD (1) | $ | 3,756 | $ | 0 | UD (1) | $ | 3,906 | $ | (−) | AD | $ | 4,056 | $ | (−) | AD | $ | 4,209 | $ | (−) | AD | ||
| 70% | ST 5: Colonoscopy | 15.205 | 3,590 | 959 | $ | 4,005 | $ | 232,391 | UD (3) | $ | 4,005 | $ | 187,455 | UD (2) | $ | 4,005 | $ | 140,232 | UD (2) | $ | 4,005 | $ | 108,751 | UD (2) | $ | 4,005 | $ | 45,788 | UD (2) | $ | 4,005 | $ | 0 | UD (1) | $ | 4,005 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.198 | 3,774 | 767 | $ | 3,858 | $ | (−) | AD | $ | 4,005 | $ | (−) | AD | $ | 4,225 | $ | (−) | AD | $ | 4,372 | $ | (−) | AD | $ | 4,667 | $ | (−) | AD | $ | 4,961 | $ | (−) | AD | $ | 5,261 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.203 | 3,569 | 977 | $ | 3,572 | $ | 171,317 | UD (2) | $ | 3,677 | $ | 226,863 | ED | $ | 3,834 | $ | 310,182 | ED | $ | 3,938 | $ | 365,728 | ED | $ | 4,147 | $ | (−) | AD | $ | 4,356 | $ | (−) | AD | $ | 4,569 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.203 | 3,661 | 884 | $ | 3,482 | $ | 0 | UD (1) | $ | 3,557 | $ | 0 | UD (1) | $ | 3,670 | $ | 0 | UD (1) | $ | 3,746 | $ | 0 | UD (1) | $ | 3,896 | $ | 0 | UD (1) | $ | 4,047 | $ | (−) | AD | $ | 4,200 | $ | (−) | AD | ||
| 80% | ST 5: Colonoscopy | 15.236 | 3,573 | 1,025 | $ | 4,089 | $ | (−) | AD | $ | 4,089 | $ | (−) | AD | $ | 4,089 | $ | (−) | AD | $ | 4,089 | $ | (−) | AD | $ | 4,089 | $ | (−) | AD | $ | 4,089 | $ | 93,335 | UD (2) | $ | 4,089 | $ | 0 | UD (1) | |
| ST 14: Test X | 15.231 | 3,733 | 858 | $ | 3,897 | $ | (−) | AD | $ | 4,042 | $ | (−) | AD | $ | 4,259 | $ | (−) | AD | $ | 4,404 | $ | (−) | AD | $ | 4,694 | $ | (−) | AD | $ | 4,984 | $ | (−) | AD | $ | 5,280 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.237 | 3,416 | 1,176 | $ | 3,456 | $ | 0 | UD (1) | $ | 3,560 | $ | 27,255 | UD (2) | $ | 3,716 | $ | 69,153 | UD (2) | $ | 3,820 | $ | 97,086 | UD (2) | $ | 4,028 | $ | 152,950 | UD (2) | $ | 4,236 | $ | 510,354 | UD (3) | $ | 4,448 | $ | 1,246,300 | UD (2) | ||
| ST 16: Test X 5 | 15.236 | 3,551 | 1,045 | $ | 3,457 | $ | (−) | AD | $ | 3,532 | $ | 0 | UD (1) | $ | 3,644 | $ | 0 | UD (1) | $ | 3,719 | $ | 0 | UD (1) | $ | 3,869 | $ | 0 | UD (1) | $ | 4,019 | $ | 0 | UD (1) | $ | 4,172 | $ | (−) | AD | ||
| 90% | ST 5: Colonoscopy | 15.207 | 3,518 | 1,038 | $ | 3,949 | $ | (−) | AD | $ | 3,949 | $ | (−) | AD | $ | 3,949 | $ | (−) | AD | $ | 3,949 | $ | (−) | AD | $ | 3,949 | $ | (−) | AD | $ | 3,949 | $ | (−) | AD | $ | 3,949 | $ | (−) | AD | |
| ST 14: Test X | 15.202 | 3,644 | 907 | $ | 3,790 | $ | (−) | AD | $ | 3,937 | $ | (−) | AD | $ | 4,158 | $ | (−) | AD | $ | 4,305 | $ | (−) | AD | $ | 4,599 | $ | (−) | AD | $ | 4,893 | $ | (−) | AD | $ | 5,193 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.208 | 3,326 | 1,231 | $ | 3,281 | $ | (−) | AD | $ | 3,386 | $ | (−) | AD | $ | 3,542 | $ | (−) | AD | $ | 3,647 | $ | (−) | AD | $ | 3,856 | $ | (−) | AD | $ | 4,066 | $ | (−) | AD | $ | 4,279 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.210 | 3,389 | 1,168 | $ | 3,192 | $ | 0 | UD (1) | $ | 3,267 | $ | 0 | UD (1) | $ | 3,380 | $ | 0 | UD (1) | $ | 3,455 | $ | 0 | UD (1) | $ | 3,605 | $ | 0 | UD (1) | $ | 3,756 | $ | 0 | UD (1) | $ | 3,909 | $ | 0 | UD (1) | ||
| 100% | ST 5: Colonoscopy | 15.203 | 3,530 | 1,096 | $ | 4,018 | $ | (−) | AD | $ | 4,018 | $ | (−) | AD | $ | 4,018 | $ | (−) | AD | $ | 4,018 | $ | (−) | AD | $ | 4,018 | $ | (−) | AD | $ | 4,018 | $ | (−) | AD | $ | 4,018 | $ | (−) | AD | |
| ST 14: Test X | 15.197 | 3,627 | 997 | $ | 3,830 | $ | (−) | AD | $ | 3,976 | $ | (−) | AD | $ | 4,195 | $ | (−) | AD | $ | 4,341 | $ | (−) | AD | $ | 4,633 | $ | (−) | AD | $ | 4,925 | $ | (−) | AD | $ | 5,223 | $ | (−) | AD | ||
| ST 15: Test X 3 | 15.204 | 3,254 | 1,379 | $ | 3,304 | $ | (−) | AD | $ | 3,408 | $ | (−) | AD | $ | 3,564 | $ | (−) | AD | $ | 3,668 | $ | (−) | AD | $ | 3,876 | $ | (−) | AD | $ | 4,084 | $ | (−) | AD | $ | 4,296 | $ | (−) | AD | ||
| ST 16: Test X 5 | 15.205 | 3,328 | 1,307 | $ | 3,218 | $ | 0 | UD (1) | $ | 3,294 | $ | 0 | UD (1) | $ | 3,406 | $ | 0 | UD (1) | $ | 3,482 | $ | 0 | UD (1) | $ | 3,632 | $ | 0 | UD (1) | $ | 3,782 | $ | 0 | UD (1) | $ | 3,936 | $ | 0 | UD (1) | ||
In each analysis, the most effective strategy with an ICER of less than a willingness to pay of $50,000 per life year gained was highlighted. If this strategy was colonoscopy it was highlighted in orange, if it was Test X, it was highlighted in green.
In each group of 6 rows an upper orange triangle and a lower green triangle were formed, indicating that Test X would be competitive to colnoscopy in the middle rows and columns
LY: Life Years. CRC: Colorectal Cancer. ICER: Incremental Cost Effectiveness Ratio. (−) negative value. AD: Absolute Dominance. ED: Extended Dominance. UD: Undominated.