FIG 4.

Application of the equations derived from the simulation data to data for another 11 HD patients. The dotted line in each diagram indicates the simulated plasma concentrations of ertapenem following the 500-mg thrice-weekly administration, after each session of HD. The trough concentrations observed for each dosing interval are indicated as open circles. The vertical axis in each diagram indicates the total ertapenem plasma level (milligrams per liter), and the horizontal axis indicates the time (hours). The diagram in the bottom right shows the correlation between observed (Obs) and predicted (Pred) data for patients 12 to 22, using the simulation model.