TABLE 1.
Basic characteristics and clinical data for infected HD patients who received ertapenem treatment during hospitalization (n = 22)a
| Characteristicb | Reference groupc (n = 11) | Experimental groupd (n = 11) | P |
|---|---|---|---|
| Age (yr) | 63.2 ± 16.6 | 66.4 ± 16.1 | 0.653 |
| No. male/no. female | 4/7 | 4/7 | 0.67 |
| Body height (cm) | 159.7 ± 10.8 | 159.1 ± 10.7 | 0.906 |
| Body weight (kg) | 60.3 ± 14.1 | 62.0 ± 17.4 | 0.804 |
| Total body fluid removal (liters) | 1.4 ± 1.3 | 1.7 ± 1.1 | 0.602 |
| Systolic BP (mm Hg) | 136.0 ± 25.2 | 140.8 ± 23.7 | 0.649 |
| Diastolic BP (mm Hg) | 79.7 ± 17.8 | 80.8 ± 12.0 | 0.868 |
| Blood flow in HD (ml/min) | 201.8 ± 41.4 | 210.5 ± 26.5 | 0.567 |
| Dialysate flow in HD (ml/min) | 500 | 500 | 1 |
| Kt/V | 1.6 ± 0.2 | 1.4 ± 0.4 | 0.108 |
| URR (%) | 73.5 ± 5.0 | 69.3 ± 9.3 | 0.209 |
| Albumin level (g/dl) | 3.3 ± 0.3 | 3.2 ± 0.6 | 0.934 |
| BUN level (mg/dl) | 63.7 ± 17.9 | 80.7 ± 23.1 | 0.068 |
| Cr level (mg/dl) | 8.2 ± 2.6 | 8.3 ± 1.7 | 0.929 |
a
All patients were local HD patients in Taiwan.
b
Kt/V, dialysis efficiency; URR, urea reduction rate; BUN, blood urea nitrogen; Cr, creatinine. Continuous variables are shown as mean ± standard deviation. The normal range for albumin levels is 3.5 to 5.7 mg/dl, that for blood urea nitrogen levels is 7 to 25 mg/dl, and that for creatinine levels is 0.6 to 1.3 mg/dl.
c
In the reference group, HD patients received ertapenem at 500 mg daily.
d
In the experimental group, HD patients received ertapenem at 500 mg thrice weekly, after each HD session.