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. 2019 Nov 21;63(12):e01435-19. doi: 10.1128/AAC.01435-19

TABLE 3.

Initial assumptions on effectiveness of TDM interventions in GVHD population for model 2

Quartile Posaconazole exposure (ng/ml) (median [range]) % of patients remaining in quartiles of posaconazole exposure after TDM intervention
No TDMa Minimally effective Moderately effective Maximally effective
Oral suspension
    Quartile 1 289 (21.5–557) 25 15 5 0
    Quartile 2 736 (557–915) 25 30 25 15
    Quartile 3 1,239 (915–1,563) 25 30 40 55
    Quartile 4 2,607 (1,563–3,650) 25 25 30 30
Tablet
    Quartile 1 289 (21.5–557) 5 2.5 0 0
    Quartile 2 736 (557–915) 5 7.5 5 0
    Quartile 3 1,239 (915–1,563) 60 60 65 60
    Quartile 4 2,607 (1,563–3,650) 30 30 30 40
a

Distribution of posaconazole plasma concentrations were derived from pharmacokinetic/pharmacodynamic analysis by Jang et al. (8) and Cornely et al. (14).