TABLE 3.
Cefepime time above MIC targets for each organism in the neutropenic mouse pneumonia model under conditions of coadministration of cefepime and zidebactam
| Organism | MIC (mg/liter) | Cefepime plasma concn (24-h %T>MIC) |
|
|---|---|---|---|
| Stasis | 1 log | ||
| E. coli BAA-2452 | 0.25 | 9.83 | 19.72 |
| E. coli 2671 | 0.125 | 10.84 | 16.22 |
| K. pneumoniae NCTC 13443 | 2 | 3.61 | 10.15 |
| K. pneumoniae BAA-2146 | 1 | 8.53 | 12.70 |
| K. pneumoniae 53816 | 0.25 | 27.75 | 49.10 |
| K. pneumoniae 1104866 | 0.25 | 37.49 | 61.81 |
| K. pneumoniae 2693 | 1 | 30.24 | 47.56 |
| K. pneumoniae 2697 | 0.125 | 15.17 | 26.66 |
| Mean | 17.93 | 30.49 | |
| Median | 13.0 | 23.19 | |
| SD | 12.23 | 19.58 | |
| SE of the mean | 4.3 | 6.9 | |