TABLE 1.
MICs of β-lactams for K. pneumoniae clinical isolates, E. coli TOP10 transformants, and E. coli TOP10 recipient strains
| β-Lactama | MIC (μg/ml) |
||||
|---|---|---|---|---|---|
|
K. pneumoniae |
E. coli |
||||
|
UM (KPC-41) |
FF (KPC-3) |
TOP10 (pTOPO-KPC-41) |
TOP10 (pTOPO-KPC-3) |
TOP10 | |
| Amoxicillin | >128 | >128 | >128 | >128 | 8 |
| Amoxicillin + CLA | >128 | >128 | >128 | >128 | 8 |
| Ticarcillin | >128 | >128 | >128 | >128 | 4 |
| Ticarcillin + CLA | >128 | >128 | >128 | >128 | 4 |
| Piperacillin | >128 | >128 | 128 | >128 | 2 |
| Piperacillin + TZB | >128 | >128 | 128 | >128 | 2 |
| Cephalothin | >128 | >128 | >128 | >128 | 16 |
| Cefotaxime | 32 | >128 | 16 | >128 | <0.125 |
| Ceftazidime | 1,024 | 1,024 | 2,048 | 2,048 | 0.25 |
| Ceftazidime + AVI | >128 | 4 | 128 | 2 | 0.25 |
| Ceftaroline | >256 | >256 | >256 | >256 | 0.25 |
| Cefepime | 16 | 128 | 16 | 128 | <0.125 |
| Ceftolozane + TZB | >256 | 64 | >256 | >256 | 0.06 |
| Cefoxitin | 32 | 32 | 8 | 128 | 8 |
| Aztreonam | >128 | >128 | 64 | 64 | <0.125 |
| Imipenem | 4 | 8 | 2 | 32 | 0.25 |
| Meropenem | 1 | 8 | 0.5 | 16 | 0.5 |
| Ertapenem | 4 | 16 | 0.5 | 32 | <0.12 |
a
Clavulanic acid (CLA) was added at a fixed of 2 μg/ml, tazobactam (TZB) at 4 μg/ml, and avibactam at 4 μg/ml.