TABLE 6.

Observed and PD model-predicted EBA as fall in log₁₀ CFU/ml sputum/day for CL-010 and CL-007

Groupa	Mean (SD) value forb :
	EBA0–2		EBA2–14		EBA0–14
	Obs [n]	Pred	Obs [n]	Pred	Obs [n]	Pred
CL-010
50 mg	0.093 (0.211) [14]	0.042 (0.037)	0.059 (0.060) [12]	0.057 (0.046)	0.063 (0.058) [12]	0.055 (0.045)
100 mg	0.111 (0.332) [15]	0.064 (0.050)	0.088 (0.085) [15]	0.081 (0.059)	0.091 (0.073) [15]	0.079 (0.057)
150 mg	−0.009 (0.290) [15]	0.076 (0.056)	0.096 (0.098) [14]	0.094 (0.065)	0.078 (0.074) [14]	0.091 (0.063)
200 mg	0.160 (0.255) [14]	0.084 (0.061)	0.104 (0.083) [14]	0.100 (0.068)	0.112 (0.070) [14]	0.099 (0.067)
CL-007
200 mg	0.109 (0.487) [15]	0.084 (0.061)	0.106 (0.063) [12]	0.100 (0.068)	0.106 (0.049) [12]	0.099 (0.067)
600 mg	0.096 (0.226) [13]	0.110 (0.073)	0.113 (0.079) [12]	0.120 (0.077)	0.107 (0.053) [14]	0.120 (0.076)
1,000 mg	0.025 (0.340) [15]	0.110 (0.077)	0.095 (0.062) [14]	0.130 (0.079)	0.091 (0.083) [15]	0.130 (0.078)
1,200 mg	−0.035 (0.420) [15]	0.120 (0.078)	0.113 (0.099) [11]	0.130 (0.080)	0.088 (0.084) [11]	0.130 (0.079)

^aPretomanid treatment group.

^bThe values shown represent the fall in log₁₀ CFU/ml sputum/day during treatment days 0 to 2 (EBA_0–2), 2 to 14 (EBA_2–14), and 0 to 14 (EBA_0–14) in the CL-007 and CL-010 studies. EBA, early bactericidal activity; Obs, observed value; [n], number of participants for observed data; Pred, predicted value (sample size equal to 10,000). Observed values for the CL-007 and CL-010 studies are from references 13 and 14, respectively, by Diacon et al.