. 2019 Nov 21;63(12):e00732-19. doi: 10.1128/AAC.00732-19

TABLE 8.

Dose-response model parameter values for EBA calculated from MC simulation mean CFU and TTP profiles

EBA parameter^a	Mean (SE) value for^b :
	EBA_0–2		EBA_2–14		EBA_0–14
	E_max	D₅₀	E_max	D₅₀	E_max	D₅₀
CFU count
q.d.	0.125 (0.0003) log₁₀ CFU/ml/day	98 (0.9) mg	0.137 (0.0001) log₁₀ CFU/ml/day	70 (0.4) mg	0.136 (0.0001) log₁₀ CFU/ml/day	73 (0.4) mg
b.i.d.	0.136 (0.0001) log₁₀ CFU/ml/day	61 (0.2) mg	0.148 (0.002) log₁₀ CFU/ml/day	37 (0.2) mg	0.146 (0.0001) log₁₀ CFU/ml/day	40 (0.3) mg
TTP
q.d.	5.96 (0.02) h/day	97 (1.0) mg	6.61 (0.004) h/day	71 (0.2) mg	6.51 (0.005) h/day	74 (0.3) mg
b.i.d.	6.48 (0.008) h/day	62 (0.3) mg	7.16 (0.007) h/day	38 (0.2) mg	7.06 (0.009) h/day	41 (0.3) mg

q.d., once daily; b.i.d., twice daily.

The values shown represent the parameter estimate (standard error [SE]) for the maximum effect (E_max) and half-maximum effect dose (D₅₀) for treatment days 0 to 2 (EBA_0–2), 2 to 14 (EBA_2–14), and 0 to 14 (EBA_0–14). EBA was calculated with CFU counts as log₁₀ CFU/ml/day or with TTP as hours/day. The sample size was 10,000.