TABLE 1.
Impact of mexZ and armZ mutations on antimicrobial resistance of P. aeruginosa PAO1161a
| Modified allele(s) of strain PAO1161 Rifr | MIC (μg/ml) |
|||
|---|---|---|---|---|
| Amikacin | Gentamicin | Tobramycin | Tetracycline | |
| None (WT) | 4 | 2 | 1 | 64 |
| ΔmexZ | 8 | 4 | 1 | 64 |
| ΔarmZ | 1 | 0.5 | 0.25 | 16 |
| ΔmexZ ΔarmZ | 8 | 4 | 1 | 64 |
| mexZR3S | 8 | 4 | 1 | 64 |
| mexZK6E | 4 | 2 | 0.5 | 64 |
| mexZR13H | 8 | 4 | 1 | 64 |
| mexZK53E | 2 | 1 | 0.25 | 32 |
a
Data represent MICs of the indicated antibiotics assayed with a microdilution method in cation-adjusted Mueller-Hinton medium. MIC analysis was performed twice, with identical results.