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. 2019 Nov 21;63(12):e01653-19. doi: 10.1128/AAC.01653-19

TABLE 1.

Parameters obtained with the software CompuSyn to describe the synergistic effect of favipiravir and ribavirina

Ribavirin + favipiravir doseb Effect (Fa)c Dosed (μM)
 DRIe
CIf
Ribavirin Favipiravir Ribavirin Favipiravir
5 + 5 0.5101 12.4563 14.4863 2.49126 2.89727 0.74656
5 + 20 0.7059 22.0253 54.2846 4.40506 2.71423 0.59544
5 + 50 0.6935 21.1558 49.4461 4.23115 0.98892 1.24755
5 + 400 0.9338 73.7638 893.946 14.7528 2.23486 0.51524
10 + 5 0.7065 22.0688 54.5335 2.20688 10.9067 0.54481
10 + 20 0.7109 22.3922 56.4033 2.23922 2.82017 0.80117
10 + 50 0.8441 38.3742 196.573 3.83742 3.93147 0.51495
10 + 400 0.9547 97.0170 1687.07 9.70170 4.21768 0.34017
20 + 5 0.8421 37.9802 191.928 1.89901 38.3856 0.55264
20 + 20 0.8785 46.7487 310.618 2.33743 15.5309 0.49221
20 + 50 0.8751 45.7551 295.531 2.28776 5.91061 0.60630
20 + 400 0.9952 461.821 62,762.4 23.0911 156.906 0.04968
50 + 5 0.9494 89.6197 1,403.78 1.79239 280.757 0.56147
50 + 20 0.9650 116.543 2,580.56 2.33086 129.028 0.43678
50 + 50 0.9804 174.998 6,620.73 3.49996 132.415 0.29327
50 + 400 0.9968 609.716 119,493.0 12.1943 298.733 0.08535
a

The viral populations analyzed are described in Fig. 3.

b

Dose (concentration) of drug (in micromolar).

c

Fa, the fraction of the population that is affected by the dose.

d

The dose of a single drug that exhibits a given percent inhibition.

e

DRI, dose reduction index, calculated by the equation of Chou: DRI = Dx/D, where Dx is the dose of a single drug that exhibits a given percent inhibition, and D is the dose (69).

f

CI, combination index, which is calculated with the formula CI = D1/Dx1 + D2/Dx2, where D1 and D2 are the doses of ribavirin and favipiravir, respectively, and Dx1 and Dx2 are the doses of ribavirin and favipiravir that exhibit a given percent inhibition, respectively.