TABLE 2.

Statistical analysis of the difference between the nucleotides present on the 5′ or 3′ side of the indicated mutation type in HCV populations passaged in the absence and presence of favipiravir and ribavirin^a

Mutation type	Side of immediate neighbors	Nucleotideb	Comparison	No.c	P value		Significanced
					Proportion test	Bonferroni correction
G → A	5′	A	Favipiravir	95	0.00054	0.00216	**
			Ribavirin	55
		C	Favipiravir	28	0.02530	0.10100	NS
			Ribavirin	42
		G	Favipiravir	37	0.29800	1.00000	NS
			Ribavirin	42
		U	Favipiravir	14	0.38700	1.00000	NS
			Ribavirin	18
C → U	3′	A	Favipiravir	43	0.229000	0.917	NS
			Ribavirin	57
		C	Favipiravir	58	0.260000	1.00000	NS
			Ribavirin	73
		G	Favipiravir	34	0.015400	0.0614	NS
			Ribavirin	58
		U	Favipiravir	96	0.000011	0.0000439	***
			Ribavirin	54
C → U	3′	A	Favipiravir	43	0.013100	0.05250	NS
			No drug	26
		C	Favipiravir	58	0.971000	1.00000	NS
			No drug	19
		G	Favipiravir	34	0.083900	0.33500	NS
			No drug	19
		U	Favipiravir	96	0.000509	0.00203	**
			No drug	15

^aThe viral populations analyzed are described in Fig. 3.

^bThe nucleotide which is the 5′ or 3′ neighbor (indicated in the second column) of the mutation type given in the first column.

^cNumber of times that the nucleotide is a neighbor to a mutation, without considering the haplotype abundance or the number of haplotypes in which a given mutation was present.

^dThe statistical significance of the differences is given as follows: NS, not significant; **, P < 0.01; ***, P < 0.001.