Skip to main content
. 2019 Nov 21;63(12):e01067-19. doi: 10.1128/AAC.01067-19

TABLE 1.

k13 SNP frequenciesa

Codon Nucleotide Codon (nucleotide) for:
 Frequency (% [no.]) during yr:
Wild type Mutant 1995/1996 1998/1999 2005/2006 2012/2013 2015/2016
38 112 S (A) C (T) 0 (132) 0 (117) 0 (133) 0 (114) 0.7 (135)
96 287 P (C) Q (A) 0 (132) 0.7 (126) 0 (133) 0 (114) 0 (137)
108 322 K (A) E (G) 0 (95) 0.7 (126) 0.7 (133) 0 (114) 0 (137)
119b 355 L (T) L (C) 0.7 (132) 0 (126) 0.7 (133) 0 (114) 0 (136)
126b 377 T (C) N (A) 0.7 (132) 0.7 (126) 0 (133) 0 (114) 0 (136)
134 401 I (T) S (G) 0 (126) 0.7 (126) 0 (133) 0 (114) 0 (135)
136 406 H (C) N (A) 0.7 (126) 0 (126) 0.7 (133) 1 (115) 0 (135)
137b ,c 409 Nx6 (6xAAT) Nx7 (7xAAT) 2 (124) 1 (126) 3 (133) 3 (115) 0.7 (134)
Nx8 (8xAAT) 3 (124) 1 (126) 0 (133) 1 (115) 1 (134)
Nx9 (9xTAA) 0 (124) 0 (126) 0 (133) 1 (115) 0 (134)
Nx10 (10xTAA) 0 (124) 0 (126) 0 (133) 1 (115) 0 (134)
148 443 I (T) T (C) 0 (122) 0 (104) 0.7 (133) 0 (114) 0 (133)
149b 445 T (A) S (T) 0 (122) 0.7 (127) 0 (133) 0 (114) 1 (133)
157b 469 M (A) V (G) 0 (122) 0.7 (127) 0 (133) 0 (114) 0 (132)
174 520 A (G) S (T) 0 (95) 0 (125) 0 (133) 0.8 (115) 0 (83)
178b 532 I (A) L (T) 1 (86) 0 (126) 0 (128) 0 (108) 0 (68)
182b 544 S (T) T (A) 0 (95) 3 (125) 1 (132) 0 (117) 0 (87)
189b 566 K (A) T (C) 8 (82) 15 (126) 10.6 (132) 15 (115) 13 (71)
567 K (A) T (T) 0 (79) 0 (124) 0.7 (132) 0.8 (115) 0 (71)
192c 574 T (A) A (G) 0 (72) 0 (125) 0.7 (131) 0 (104) 0 (74)
258b 772 L (T) M (A) 1 (91) 1 (100) 0 (105) 0 (79) 0.8 (116)
271b 813 Q (G) H (T) 0 (93) 0 (69) 0.9 (107) 0 (81) 0 (121)
354 1060 I (A) V (G) 0.7 (132) 0 (136) 0 (126) 0 (103) 0 (138)
417b 1251 P (C) P (T) 0.7 (135) 0 (140) 0.7 (126) 0 (105) 0 (129)
469b 1407 C (C) C (T) 0 (138) 0 (139) 2 (126) 0 (102) 0 (139)
487 1461 V (A) V (T) 0 (139) 0.7 (127) 0 (130) 0 (105) 0 (142)
578b ,c 1732 A (G) S (T) 1 (137) 0.7 (127) 0.7 (127) 0 (117) 0.7 (142)
1733 A (C) V (T) 0.7 (137) 0 (131) 0 (127) 0 (117) 0 (142)
589b 1767 V (C) V (T) 0 (136) 0 (123) 0 (127) 0 (117) 0.7 (139)
a

The numbers of samples successfully genotyped per time point include 148 in 1995/1996, 146 in 1998/1999, 146 in 2005/2006, 132 in 2012/2013, and 148 in 2015/2016. No sequences with mixed bases were identified. Frequency data are presented as the percentage of sequences that carried a mutation out of the total number of sequences that had data for that locus (n). Polymorphisms in codons 30 to 417 fall in the N-terminal region, while those from 469 to 589 fall in the C-terminal region. SNPs not marked as described in footnotes b and c appear to be unique to the Kilifi parasite population. In gray are frequencies of zero.

b

N-terminal SNPs that have been identified in parasites from Africa.

c

N-terminal SNPs that have been identified in parasites from SE Asia.