TABLE 3.

Plasma PK parameters of AT-511 and AT-273

Analyte and study part	Dose, mg/day (n = 6)	Cmax (ng/ml), mean ± SD		Tmax (h), median (range)		AUCb (ng/ml · h), mean ± SD		T1/2 (h), mean ± SD		C24hc (ng/ml), mean ± SD
		Day 1	SSa	Day 1	SS	Day 1	SS	Day 1	SS	Day 1	SSc
AT-511
C	150	573 ± 280	462 ± 409	0.5 (0.5–1.0)	1.0 (0.5–1.0)	492 ± 141	475 ± 301	0.62 ± 0.11	0.64 ± 0.20
	300	2,277 ± 893	1,834 ± 1,313	0.5 (0.5–0.9)	0.5 (0.4–1.0)	1,947 ± 1,120	1,510 ± 976	0.80 ± 0.18	0.73 ± 0.15
	600	4,211 ± 2,302	3,604 ± 1,742	0.5 (0.5–0.5)	0.5 (0.5–1.0)	3,335 ± 1,502	4,036 ± 2,093	0.86 ± 0.11	0.85 ± 0.12
D	600	3,971 ± 1,943	4,144 ± 2,280	0.5 (0.5–0.5)	0.5 (0.5–1.0)	3,333 ± 1,241	3,754 ± 2,275	0.73 ± 0.12	0.83 ± 0.06
E	600	3,412 ± 2,175	3,192 ± 2,085	0.5 (0.5–1.0)	0.5 (0.5–1.0)	3,323 ± 1,467	3,527 ± 1,605	0.86 ± 0.18	0.81 ± 0.12
AT-273
C	150	75.6 ± 15.4	81.1 ± 33.9	4.0 (4.0–6.0)	4.0 (4.0–8.0)	800 ± 213	962 ± 409		12.5 ± 6.33	8.08 ± 3.48	12.8 ± 4.45
	300	123 ± 16.6	220 ± 203	4.0 (2.9–6.0)	4.0 (2.0–5.9)	1,414 ± 220	1,828 ± 453		24.5 ± 15.3	18.0 ± 8.83	26.1 ± 7.56
	600	197 ± 57.1	233 ± 42.9	5.0 (4.0–6.0)	4.0 (4.0–6.0)	2,204 ± 486	2,839 ± 572		28.9 ± 14.4	27.5 ± 5.21	46.9 ± 15.5
D	600	195 ± 42.9	263 ± 104	5.0 (3.0–6.0)	4.0 (4.0–6.0)	2,253 ± 595	3,117 ± 1,048		27.9 ± 18.3	30.1 ± 10.9	37.8 ± 11.4
E	600	201 ± 68.1	255 ± 95.4	5.0 (3.0–6.0)	6.0 (4.0–6.0)	2,625 ± 873	3,569 ± 1,214		24.4 ± 9.81	41.6 ± 12.9	69.9 ± 18.5

^aSS, steady state.

^bAUC_inf for AT-511 and AUCτ for AT-273.

^cC₂₄ reported for only AT-273; C₂₄ at steady state was the mean of C₂₄ at 72, 96, 120, 144, and 168 h.