TABLE 2.
Typical PBP2a mutations associated with ceftaroline resistance
| Mutation(s)a | Reference(s) |
|---|---|
| Asn104Lys | 28 |
| Val117Ile | 28 |
| Met122Ile | 29 |
| Asp139Trp | 24 |
| Asn146Lys | 23, 24, 28, 30–33, 113 |
| Glu150Lys | 29, 31, 113 |
| Glu170Lys | 24 |
| Val117Ile | 28 |
| Asn204Lys | 23, 24, 30 |
| Asn206Lys | 33 |
| Asp208Glu | 33 |
| Ser225Arg | 23 |
| Ala228Val | 28 |
| Thr235Ile | 33 |
| Asn236Lys | 23 |
| Glu239Lys | 24, 30–32, 122 |
| Gly246Glu | 23, 31, 113 |
| Lys281Arg | 24 |
| His351Asn, H351Gln* | 24, 113 |
| Leu357Ile* | 28 |
| Tyr446Asn* | 115 |
| Glu447Lys* | 24, 28, 32, 122 |
| Ile563Thr* | 28 |
| Ser649Ala* | 28 |
a
*, in the penicillin-binding domain.