TABLE 1.
Inhibitory activity of known antifungal drugs against Cryptococcus yeast growth and spore germinationa
| Known antifungal drugs | Yeast growth (%OD600) | Spore germination (% luciferase signal) |
|---|---|---|
| No drug | 100.0 | 100.0 |
| Butenafine HCl | 32.9 | 57.5 |
| Econazole nitrate | 33.1 | 16.1 |
| Bifonazole | 33.4 | 13.6 |
| Butoconazole nitrate | 33.4 | 41.5 |
| Clotrimazole | 34.1 | 65.9 |
| Naftifine HCl | 34.5 | 55.5 |
| Climbazole | 34.8 | 151.5 |
| Ketoconazole | 35.4 | 154.8 |
| Voriconazole | 35.8 | 173.9 |
| Fenticonazole nitrate | 36.4 | 49.1 |
| Tioconazole | 36.8 | 25.0 |
| Isoconazole nitrate | 37.0 | 16.8 |
| Liranaftate | 37.6 | 64.8 |
| Miconazole nitrate | 38.2 | 25.5 |
| Pentamidine HCl | 38.3 | 6.5 |
| Sulconazole nitrate | 40.9 | 57.8 |
| Amorolfine hydrochloride | 41.4 | 88.6 |
| Amphotericin B | 45.7 | 84.6 |
| Posaconazole | 46.7 | 167.2 |
| Tolnaftate | 47.3 | 60.2 |
| Caspofungin acetate | 48.5 | 89.7 |
| Itraconazole | 58.9 | 159.6 |
| Fluconazole | 72.2 | 84.0 |
| Flucytosine | 96.4 | 102.0 |
a
Inhibitors of spore germination are indicated by gray shading.