TABLE 2.
Inhibitory activity of known antifungal drugs against Cryptococcus yeast growth and spore germination, with designations as listed by the L1300 Selleck FDA-approved drug librarya
| Drug | Yeast growth (%OD600) | Spore germination (% luciferase signal) | Designation |
|---|---|---|---|
| Otilonium bromide | 29.0 | 6.9 | Cardiovascular disease |
| Alexidine HCl | 29.6 | 4.6 | |
| Benzethonium chloride | 30.3 | 6.9 | Neurological disease |
| Clomifene citrate | 30.7 | 66.0 | Cancer |
| Tamoxifen citrate | 31.4 | 71.7 | Endocrinology |
| Cetylpyridinium chloride | 31.9 | 4.2 | Infection |
| Mizolastine | 32.7 | 144.5 | |
| Terbinafine | 32.9 | 54.3 | Infection |
| Arecoline | 33.2 | 79.5 | Endocrinology |
| 10-DAB | 34.6 | 104.1 | Cancer |
| Irbesartan | 34.9 | 180.8 | |
| Vincristine | 35.5 | 99.7 | Cancer |
| Chloroxine | 35.9 | 41.9 | Infection |
| Rivastigmine tartrate | 36.5 | 99.4 | Cardiovascular disease |
| Betaxolol | 37.1 | 102.5 | Cardiovascular disease |
| AMG-073 HCl | 37.5 | 53.2 | Endocrinology |
| Cyproheptadine HCl | 37.8 | 90.7 | Neurological disease |
| Toremifene citrate | 38.1 | 80.3 | Endocrinology |
| Cytidine | 38.4 | 114.9 | Cardiovascular disease |
| Mexiletine HCl | 39.0 | 98.3 | Cardiovascular disease |
| Azasetron HCl | 39.1 | 98.4 | |
| Zalcitabine | 40.1 | 96.5 | Infection |
| Primidone | 42.3 | 99.5 | Neurological disease |
| Isradipine | 42.7 | 66.7 | Neurological disease |
| Epalrestat | 42.9 | 68.8 | Inflammation |
| Niclosamide | 43.4 | 7.8 | |
| Metoprolol tartrate | 43.5 | 97.3 | Cardiovascular disease |
| Dasatinib | 44.7 | 53.3 | Cancer |
| Besifloxacin HCl | 44.7 | 123.4 | |
| Broxyquinoline | 46.0 | 79.6 | Vermifuge |
| Daptomycin | 46.0 | 98.2 | |
| Metolazone | 46.7 | 93.6 | Cardiovascular disease |
| Dequalinium chloride | 47.9 | 22.3 | |
| Hygromycin B | 49.2 | 72.4 | |
| Cefdinir | 50.0 | 80.4 | Infection |
| Ezetimibe | 51.3 | 22.0 | Cardiovascular disease |
| Benazepril HCl | 52.6 | 39.4 | Cardiovascular disease |
| Doxercalciferol | 55.2 | 17.1 | Endocrinology |
| Methimazole | 55.9 | 97.4 | Endocrinology |
| Deferiprone | 56.2 | 68.3 | |
| Biperiden HCl | 56.6 | 23.4 | Neurological disease |
| Alverine citrate | 56.8 | 78.2 | Digestive system disease |
| Tolfenamic acid | 58.9 | 71.4 | Inflammation |
| Temsirolimus | 59.2 | 21.3 | Cancer |
| Ethambutol HCl | 61.3 | 92.5 | Neurological disease |
| Rapamycin | 61.8 | 18.5 | Immunology |
| Cetrimonium bromide | 63.2 | 4.4 | Infection |
| Domiphen bromide | 63.9 | 4.4 | Infection |
| Disulfiram | 65.6 | 22.7 | Neurological disease |
| Mycophenolate mofetil | 65.8 | 51.0 | Immunology |
| Famciclovir | 66.6 | 80.2 | Cancer |
| Everolimus | 67.7 | 15.7 | Cancer |
| Metformin HCl | 67.9 | 96.5 | |
| Entacapone | 69.0 | 75.2 | Neurological disease |
| Sasapyrine | 69.6 | 84.3 | Inflammation |
| PCI-32765 | 70.3 | 10.6 | Neurological disease |
| Allylthiourea | 70.9 | 69.5 | Metabolic disease |
| Imidapril | 73.0 | 110.7 | Cardiovascular disease |
| Riluzole | 73.7 | 85.4 | Neurological disease |
| Disodium cromoglycate | 74.9 | 93.8 | |
| Sulfanilamide | 87.5 | 21.0 | Infection |
| Ethinyl estradiol | 93.1 | 20.2 | Endocrinology |
| Candesartan cilexetil | 99.4 | 28.8 | Cardiovascular disease |
| Triclabendazole | 106.0 | 9.10 | Vermifuge |
| Aripiprazole | 110.0 | 21.3 | Neurological disease |
a
Inhibitors of spore germination are indicated by dark-gray shading. Inhibitors of germination only are indicated by light-gray shading.