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. 2019 Nov 22;57(12):e01347-19. doi: 10.1128/JCM.01347-19

TABLE 3.

IFN-γ values measured from TB antigen-tube-minus nil tube, TB antigen tube, and nil tube of TBF and QFT-GIT compared to those for TBF tubes/QFT-GIT ELISA and QFT-GIT tubes/TBF ELISAa

Tube and result Median (interquartile range) IFN-γ concn (IU/ml)
P value Kruskal-Wallis groupingb
TBF QFT-GIT TBF tubes/QFT-GIT QFT tubes/TBF
TB antigen minus nil
    Total 0.00 (0.00–0.08) 0.01 (0.00–0.09) 0.00 (0.00–0.03) 0.01 (0.00–0.09) <0.001 a, a, b, a
    Positive 1.02 (0.42–2.24) 1.30 (0.71–4.53) 1.06 (0.56–4.36) 1.20 (0.59–3.31) 0.089
    Negative 0.00 (0.00–0.04) 0.00 (0.00–0.04) 0.00 (0.00–0.02) 0.00 (0.00–0.04) <0.001 a, a, b, a
TB antigen
    Total 0.23 (0.17–0.35) 0.13 (0.07–0.31) 0.07 (0.05–0.14) 0.22 (0.16–0.39) <0.001 a, b, c, a
    Positive 1.28 (0.70–2.57) 1.52 (0.86–6.16) 1.15 (0.61–4.45) 1.53 (0.86–2.92) 0.298
    Negative 0.22 (0.17–0.29) 0.11 (0.07–0.19) 0.07 (0.04–0.11) 0.20 (0.16–0.30) <0.001 a, b, c, a
Nil
    Total 0.21 (0.17–0.29) 0.09 (0.06–0.14) 0.06 (0.04–0.10) 0.19 (0.15–0.27) <0.001 a, b, c, a
    Positive 0.25 (0.18–0.35) 0.12 (0.06–0.24) 0.07 (0.04–0.13) 0.21 (0.18–0.40) <0.001 a, b, c, a
    Negative 0.21 (0.17–0.27) 0.09 (0.06–0.15) 0.06 (0.04–0.10) 0.19 (0.15–0.26) <0.001 a, b, c, d
a

Abbreviations: TBF, Standard E TB-Feron ELISA; QFT-GIT, QuantiFERON-TB Gold In-Tube assay; QFT ELISA, QuantiFERON-TB Gold In-Tube ELISA.

b

The same letter (a) indicates nonsignificant differences between groups based on the Mann-Whitney U test or Scheffe’s multiple-comparison test.