Table 2.
Genotyping of MALAT1 polymorphisms and their association with thyroid cancer.
| SNPs | Genotypes | Cases | Controls | Pa | Adjusted OR | |||
|---|---|---|---|---|---|---|---|---|
| n = 1134 | % | n = 1228 | % | (95% CI)b | ||||
| rs11227209 | CC | 1042 | 91.97 | 1110 | 90.46 | Reference | ||
| CG | 91 | 8.03 | 110 | 8.96 | 0.389 | 0.88 (0.66-1.18) | ||
| GG | 0 | 0 | 7 | 0.57 | 0.962 | NA | ||
| Additive model | 0.09 | 0.79 (0.60-1.04) | ||||||
| Dominant model | 0.196 | 0.83 (0.62-1.10) | ||||||
| Recessive model | 0.962 | NA | ||||||
| rs619586 | AA | 1002 | 88.36 | 1051 | 85.59 | Reference | ||
| AG | 131 | 11.55 | 167 | 13.6 | 0.116 | 0.82 (0.64-1.05) | ||
| GG | 1 | 0.09 | 10 | 0.81 | 0.032 | 0.11 (0.01-0.82) | ||
| Additive model | 0.017 | 0.76 (0.60-0.95) | ||||||
| Dominant model | 0.045 | 0.78 (0.61-0.99) | ||||||
| Recessive model | 0.033 | 0.11 (0.01-0.84) | ||||||
| rs3200401 | CC | 808 | 71.32 | 872 | 71.18 | Reference | ||
| CT | 302 | 26.65 | 322 | 26.29 | 0.878 | 1.01 (0.84-1.22) | ||
| TT | 23 | 2.03 | 31 | 2.53 | 0.424 | 0.80 (0.46-1.38) | ||
| Additive model | 0.761 | 0.98 (0.83-1.14) | ||||||
| Dominant model | 0.944 | 0.99 (0.83-1.19) | ||||||
| Recessive model | 0.411 | 0.80 (0.46-1.37) | ||||||
a Two-sided χ2 test.
b Adjusted for age and sex in logistic regression model.