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. 2019 Oct 17;294(47):17863–17874. doi: 10.1074/jbc.RA119.010284

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© 2019 Zhang et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 2. — Activity of miRNAs may be reduced during reprogramming. A, the numbers of differentially expressed genes targeted by MEF-high miRNAs between MEFs and rMEFs or iPSCs. Blue and red bars represent down- and up-regulated genes targeted by the miRNAs, respectively. B, expression patterns of miRNAs targeting on down- and up-regulated genes during reprogramming. There is no significant difference in expression between the two kinds of miRNAs. Up-regulated gene-miRNA: miRNA targeting on up-regulated gene; down-regulated gene-miRNA: miRNA targeting on down-regulated gene. The error bars represent S.D. C, densities of MREs in up-regulated and down-regulated mRNA targets. There is no significant difference for MREs densities between down-regulated (mean of 0.430 MREs/kb) and up-regulated (mean of 0.487 MREs/kb; p > 0.05). D, analysis of MREs affinity in up-regulated and down-regulated mRNA targets. The ratio of 8-mer, 7-mer, and 6-mer MREs in up-regulated targets is 0.092, 0.312, and 0.292 MREs/kb, and 0.084, 0.282, and 0.269 MREs/kb in down-regulated targets, respectively.