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mTORC1 suppresses macropinocytosis in nutrient-replete environments. Growth factor–initiated PI3K/AKT/mTORC1 signaling leads to surface expression of amino acid transporters. If this results in sufficient amino acid uptake to further activate the mTOR-containing mTORC1 complex, then the mTORC1 complex suppresses the trafficking of macropinosomes to the lysosome.
