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A schematic model for the role of NLRP3 to negatively regulate Treg differentiation. NLRP3 translocates to the nucleus of CD4+ T cells by interacting with Kpna2 during Treg differentiation, followed by down-regulation of Foxp3 expression. However, the deficiency of NLRP3 in CD4+ T cells increases Foxp3 expression, resulting in better suppression of Tconv cells.
