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. 2019 Nov 26;9:17589. doi: 10.1038/s41598-019-53872-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between marker positive cell counts in large samples versus core biopsies. Correlation between number of positive-stained cells for CD8 (a–c), CD68 (d–f), CD34 (g–i), and PD-L1 (j–l) in large tissue versus cores. CD8+ correlations between large tumor samples and (a) all core biopsies, (b) central core biopsies only, and (c) peripheral core biopsies only. CD68+ correlation for (d) all core biopsies, (e) central core biopsies only, and (f) peripheral core biopsies only. CD34+ correlations for (g) all core biopsies, (h) central core biopsies only, and (i) peripheral core biopsies only. PD-L1+ correlations for (j) all core biopsies, (k) central core biopsies only, and (l) peripheral core biopsies only. Pearson correlation coefficient (R) and P values for each correlation analysis are shown in insets.