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. 2019 Nov 26;9:17589. doi: 10.1038/s41598-019-53872-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Variability between central and peripheral tumor specimens. Correlation between larger tumor specimen and increasing core biopsy number for CD8+ lymphocytes (a) peripheral core, (b) central core biopsies and CD68+ macrophages, (c) peripheral core, and (d) central core biopsies. Correlation differences between central and peripheral cores for (e) lymphocytes and (f) macrophages. P-values for Wilcoxon RankSum test are shown.