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. 2019 Nov 26;9:17598. doi: 10.1038/s41598-019-53876-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Weekly low-dose 4D μCT does not influence the general health and disease outcomes but induces a sub-clinical decrease in white blood cell and platelet counts in a murine metastasis model. Experiment 1: weekly low-dose 4D µCT scanning of metastasis-bearing mice induces a decrease in circulating platelets, increase in mean platelet volume, decrease in red blood cells and absolute white blood cell count, due to a decrease in number of lymphocytes. (A) Mouse body weight at end point. (B) In vivo BLI signal intensity expressed as total flux (p/s) from the lung, measuring metastatic load. (C) µCT-derived biomarkers (total lung volume, aerated lung volume, non-aerated lung volume and mean lung density). (D) Selected blood cell parameters: absolute platelet cell count, mean platelet volume, white blood cell count, lymphocyte count and neutrophil count and red blood cell count. Data are presented as individual values, group mean and 95% confidence intervals. P-values are presented in the graph when p < 0.05. HU, Hounsfield units.

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