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EV biogenesis. EVs are typically classed according to their biogenesis. Apoptotic bodies and microvesicles are released from the plasma membrane in blebbing and budding mechanisms, respectively. In contrast, exosomes are generated by the endolysomal pathway; internal budding of an endosome results in a multivesicular body which fuses with the plasma membrane, releasing exosomes by exocytosis.
