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. 2019 Nov 20;13:516. doi: 10.3389/fncel.2019.00516

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Copyright © 2019 Danner, Zhang, Shevtsova, Borowska-Fielding, Deska-Gauthier, Rybak and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of bilateral stimulation of V3 interneurons on flexor and extensor burst duration s and oscillation period in the model. (A) Dependence of flexor and extensor burst duration on stimulation intensity (g_ChR; shown for the left side only). Intensity of stimulation was gradually changed from 0 to 0.4. The vertical lines (1 and 2) correspond to simulations shown in Figures 8A1,A2, respectively. (B,C) Flexor and extensor burst duration and period of oscillations in a series of model experiments (n = 12) with randomly chosen parameters α and g_ChR before (gray circles) and during (blue circles) bilateral stimulation of V3 populations. Each circle represents the average value of estimated parameter for one simulation. Light blue lines connecting two circles represent parameter increase in one simulation Thick, dark blue line represent the average of increase.