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. 2019 Nov 26;10:5380. doi: 10.1038/s41467-019-13115-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Explorations on suppressed tumor recurrence using this starvation therapy. a Experiment schematic of tumor recurrence inhibition on PANC-1 tumor-bearing nude mice that received the special treatment wherein hydrogel–GNR was first injected into the surrounding periphery of PANC-1 tumor and laser (1) irradiation was carried out for triggering gelation process, followed by GNRs injection into the PANC-1 tumor and laser (2) irradiation for ablating PANC-1 tumor. b CDFI images of PANC-1 tumor and its periphery before and after the special treatment in (a). c Digital photos of nude mice-bearing PANC-1 solid tumors that experiencing two different treatments, and one is only GNRs injection in tumor uniting laser (2) irradiation for tumor ablation (designated as control group), and another is the special treatment in a (designated as experimental group), wherein yellow arrows indicate the tumor recurrence after ablation. d Quantitative statistics of tumor recurrence of PANC-1 tumor implanted on nude mice (n = 10) in c.