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. 2019 Nov 26;9:17582. doi: 10.1038/s41598-019-53640-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EV characteristics across different demographics. (A) Two EV-depleted samples as negative controls, cell lysate, and plasma EV samples were lysed with MPER, analyzed by SDS-PAGE and probed for the known EV markers CD9 and Flotillin1 (Flot1) and the purity markers GM130 and Apolipoprotein A1 (ApoA1). Full immunoblots are in Supp. Fig. 2. (B) Electron microscopy images of plasma EVs scale bar = 200 nm. (C) EV size distribution, (D) concentration, (E) size mean, and (F) size mode were analyzed across each demographic using Nanoparticle Tracking Analysis (NTA). Two-way ANOVAs tested the association of sex and race with EV size mean, size mode or concentration. Lines indicate the mean and bars indicate the standard error of the mean. AA, African American; W, white.