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. 2019 Nov 26;9:17582. doi: 10.1038/s41598-019-53640-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Apoptosis and signaling protein levels in EVs across different demographics. Plasma EVs were lysed and the indicated apoptosis-related proteins and signaling proteins were quantified using MesoScale Discovery (MSD) multispot assays. EV protein levels were log (natural logarithm) transformed and Two-way ANOVAs tested the association of sex and race with each EV protein. Lines indicate the mean and bars indicate the standard error of the mean. % p-p53 was calculated by using the p-p53 value divided by the amount of total p53. *P < 0.05 AA, African American; W, white; p, phospho.