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Incremental human plasma exposure of the P2X7 antagonist JNJ-54175446 caused a dose dependent attenuation of P2X7 dependent ex-vivo IL-1β release (ex-vivo LPS primed, ex-vivo Bz-ATP as 2nd stimulus) from human subjects (left). The dose of 50 mg JNJ-54175446 produced central target engagement as assessed by displacing the P2X7 PET ligand, [18F]JNJ-64413739 (right)
