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. 2019 Nov 26;10:5187. doi: 10.1038/s41467-019-13162-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Reductions in motivational and reinforcing properties of beer in RET + KET from Day 1 (baseline) to Day 10 (post manipulation). a Anticipated enjoyment of beer. b Post consumption actual enjoyment, c Urge to drink beer, d Post consumption urge to drink more beer. In all cases, significant reductions were observed only in RET + KET. Boxes represent mean ± IQR, whiskers represent range. Dots are individual data points. P values represent F tests on multivariate simple-effects of Time within. Source data are provided as a Source Data file