Table 2.
Spearman’s rank correlations between ketamine metabolism and primary drinking outcomes post manipulation (Day 10) and at final follow-up (9 months) time-points
| POST | 9 MONTHS | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drinking Days | Units consumed | Craving (ACQ) | AUDIT | Drinking Days | Units consumed | Craving (ACQ) | AUDIT | ||
| N = 28 | N = 19 | ||||||||
| RET | Ketamine | −0.465* | −0.543** | −0.257 | −0.175 | −0.261 | −0.449 | −0.149 | −0.44 |
| + | Norketamine | −.197 | −0.288 | −0.173 | −0.422* | −0.29 | −0.481* | 0.008 | −0.627** |
| KET | dhNK | −0.028 | −0.082 | −0.518** | −0.457* | −0.458* | −0.436 | −0.572* | −0.573** |
| N = 29 | N = 21 | ||||||||
| No | Ketamine | −0.06 | −0.177 | −0.062 | −0.184 | −0.07 | −0.02 | 0.178 | 0.09 |
| + | Norketamine | −0.015 | −0.119 | −0.109 | −0.096 | −0.022 | −0.01 | 0.122 | −0.01 |
| KET | dhNK | −0.152 | −0.018 | 0.08 | −0.033 | −0.03 | −0.051 | 0.172 | −0.022 |
Significant correlations are highlighted in bold
ACQ alcohol craving questionnaire, dhNK dehydroxynorketamine
*p < 0.05, **p < 0.01, ***p < 0.001