Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 26;10:5366. doi: 10.1038/s41467-019-13227-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — Transmission of the allosteric signal from the activation gate to the selectivity filter. a, b Visualization of the collective motion (ewMCM) of MthK that underlies SF widening at T59, in CHARMM and AMBER force fields, respectively. Lower parts of both outer and inner (M1 and M2, respectively) contribute the most to this motion. c Location of I84 in the crystal structure of MthK (PDB ID: 3LDC), in close proximity to T59. d Distance between I84 side chain (I84 CD) and T59 side chain (CG) as a function of channel opening at T59. e, f Comparison of the outward K⁺ current through MthK at 300 mV in WT and I84A mutant, for both AMBER and CHARMM force fields, respectively. g, h Correlation between AG opening (A88 CA–CA distance) and SF opening (T59 CA–CA distance) in both AMBER and CHARMM force fields, respectively. Error bars represent 95% confidence intervals. Source data are available as a Source Data file.