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Effect of MPER mutation on the neutralization of HIV COT6 by PGZL1 and control antibodies.
| Virus | MPER epitope | COT6 mutants | Fold increase in IC50 | ||||
|---|---|---|---|---|---|---|---|
| PGZL1 | H4K3 | 4E10 | 10E8 | VRC01 | |||
| COT6 | SWFDITKWLW | WT | 1 | 1 | 1 | 1 | 1 |
| PG13 Cons | NWFDITNWLW | NA | NA | NA | NA | NA | |
| PG13 isolate 1 | NWFSITNWLW | D674S | 7.7 | 6.29 | 1.65 | NA | NA |
| PG13 isolate 2 | NWFEITNWLW | D674E | 26 | 12 | 10 | 17.5 | 1.2 |
| PG13 isolate 3 | NWFTITNWLW | D674T | 120 | 38 | 25 | 36.0 | 1.0 |
NA, not attempted
